Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.190 Biomarker disease BEFREE STAT3/arginase-I signaling plays an important role in both the expansion and activation of M-MDSCs in patients with AS. 30075733 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.190 PosttranslationalModification disease BEFREE The transfection of miR-29b-1-5p mimic could inhibit the IL-23-mediated STAT3 phosphorylation and might play a role in negative feedback control in the immunopathogenesis of AS. 30463609 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.190 Biomarker disease BEFREE IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis. 29880011 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.190 Biomarker disease BEFREE Finally, it was suggested that TLR signaling pathway and T cell receptor signaling pathway may involve in the biological processes of AS progression and contribute to the curative effect and proteins such as JAK2, STAT3, HSP90AA1, TNF and PTEN were the key targets. 29044146 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.190 Biomarker disease BEFREE To establish the prevalence of the single nucleotide polymorphisms (SNPs) of endoplasmic reticulum aminopeptidase 1 (ERAP1), IL-23 receptor (IL-23R), signal transducer and activator of transcription 3 (STAT-3) and Janus kinase 2 (JAK-2) in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) in a Turkish population. 27458846 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.190 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.190 Biomarker disease BEFREE Significant up-regulation of IL-22, IL-23p19, MUC-1, and STAT-3 transcripts in the terminal ileum of patients with AS was observed. 22213179 2012
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.190 GeneticVariation disease BEFREE SNPs in TNFRSF1A (rs4149577, p = 8.2 × 10⁻⁴), STAT3 (rs2293152, p = 0.0015; rs1053005, p = 0.017) and ERAP1 (rs27038, p = 0.0091; rs27037, p = 0.0092) were significantly associated with AS in Han Chinese. 21068102 2011
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.190 GeneticVariation disease BEFREE Analysis of JAK2 and STAT3 polymorphisms in patients with ankylosing spondylitis in Chinese Han population. 20627814 2010
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.190 Biomarker disease BEFREE STAT3 is a key signaling molecule within the Th17 lymphocyte differentiation pathway and further enhances the case for a major role of this T-lymphocyte subset in ankylosing spondylitis. 21152001 2010