Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE We also detected the expression of interleukin-1 receptor-associated protein kinases-1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6) and nuclear factor-kappaB (NF-κB) p65 using Western blotting and immunohistochemistry, which indicated the expression of IRAK1, TRAF6 and NF-κB p-p65/p65 increased in the brain of SE rats, and overexpression of miR-146a-5p could downregulate the expression of IRAK1, TRAF6, NF-κB p-p65/p65 and P-gp. 31061316 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE FTY720 alleviated the overexpression of hippocampal P-gp in SE rats and reduced NF-κB activity and TNF-α and COX-2 expression, and W146 blocked the effects of FTY720. 29380527 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 Biomarker disease BEFREE H19 overexpression induced the activation of astrocytes and microglia and the release of proinflammatory cytokines (interleukin-1β and interleukin-6 and tumor necrosis factor-α) in the hippocampus, whereas H19 knockdown inhibited status epilepticus-induced glial cell activation. 29636074 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE The present pilot study aims to investigate whether liraglutide alleviates the chronic inflammation response and mitochondrial stress induced by SE in the lithium-pilocarpine animal model.We found that treatment with 25nmol/kg. i.p. once-daily after the induction of SE for 7 days reduced chronic inflammation as shown by reduced numbers of activated microglia and astrocytes, and reduced levels of TNF-α and IL-1ß in the hippocampus. 29549796 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE Rifampicin pretreatment attenuated SE-induced neuroinflammation and decreased the hippocampal expression of interleukin-1β, tumor necrosis factor-α, nuclear factor kappa-B, and cyclooxygenase-2. 30195730 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE Here, we found that TNF-α secretion and miR-155 expression levels were correlated after SE. 30006293 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE The impact of TLR3 deficiency on SE was assessed using separate cohorts of mice regarding EEG activity, seizure progression, hippocampal microglial distribution, and expression of the proinflammatory cytokines tumor necrosis factor (TNF)α and interferon (IFN)β. 28166388 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE It is widely known that SE triggers time-dependent microglial expression of pro-inflammatory cytokines that include TNFα and IL-1β. 29326654 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE In this study, we investigated the dynamic expression patterns of tumor necrosis factor alpha (TNF-α) and microRNA-155 (miR-155) in the hippocampi of an immature rat model of status epilepticus (SE) and children with MTLE. 23636891 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 Biomarker disease RGD The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations. 20649973 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 Biomarker disease CTD_human Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. 18455351 2008