Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Biomarker disease BEFREE Moreover, perampanel treatment led to reduced SE-induced caspase-3 activation in the hippocampal lysates. 30039334 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 AlteredExpression disease BEFREE In addition, resveratrol reduced activated caspase-3 activity and attenuated neuronal cell damage in the hippocampus following status epilepticus. 30823590 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 AlteredExpression disease BEFREE BoNT/A could suppress the expression of Caspase-3 and Bax, attenuate the decrease of Bcl-2, and inhibit hippocampal neuron death induced by SE. 30877518 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 AlteredExpression disease BEFREE In conclusion, TH reduced neuroinflammation and caspase-3 activity after kainic acid- (KA-) induced status epilepticus. 30108663 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Biomarker disease BEFREE These findings suggest that SE-induced aberrant mitochondrial dynamics may be involved in translocation of active caspase-3 and HMGB1 into mitochondria, which regulate neuronal apoptosis and necrosis, respectively. 30233331 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Biomarker disease BEFREE Although KA did not induce neuronal death, this study provides morphological and biochemical evidence that status epilepticus induced by KA activates caspase-3 in mossy fibers and induces autophagy in the C57BL/6 hippocampus. 28685385 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 AlteredExpression disease BEFREE Moreover, rifampicin mitigated SE-induced neuronal apoptosis as indicated by fewer positive cytochrome c immunostained cells and lower caspase-3 activity in the hippocampus. 30195730 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Therapeutic disease RGD The aim of this study was to investigate the effect of gamma-Glutamylcysteine Ethyl Ester (GCEE) on the levels of GSH, caspase-3 activity, DNA damage and the expressions of Bcl-2, Bax and p53 mRNAs in rat hippocampus after status epilepticus (SE) induced by systemic kainic acid (KA). 20214503 2010
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Biomarker disease CTD_human Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus. 18571097 2008
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Biomarker disease CTD_human In this report, in order to determine Epo preconditioning on hippocampus neuronal apoptosis, we examined caspase-3 expression following SE caused by Li-pilocarpine in rats. 16679645 2006