Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2891
Gene Symbol: GRIA2
GRIA2
0.720 Biomarker disease GENOMICS_ENGLAND AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders. 31300657 2019
Entrez Id: 2891
Gene Symbol: GRIA2
GRIA2
0.720 Biomarker disease BEFREE The present study aimed to investigate the mRNA expression of excitatory amino acid transporters 1-3 (EAATs) and the subunits of the NMDA (GluN1, GluN2a, and GluN2b) and AMPA (GluA1 and GluA2) glutamate receptors following status epilepticus in a rat lithium-pilocarpine model. 30189229 2018
Entrez Id: 2891
Gene Symbol: GRIA2
GRIA2
0.720 Biomarker disease BEFREE In the present study, we divided pilocarpine-induced SE Wistar rats into three main groups: the TAT-GluA2NT1-3-2 peptide group, the TAT-GluA2NT-scram peptide group, and the normal saline group, and injected different doses of peptides stereotaxically into the hippocampus of SE rats to investigate whether the GluA2/GAPDH interaction could be disrupted by our TAT-GluA2NT1-3-2 peptide and determine its most appropriate dose. 29489588 2018
Entrez Id: 2891
Gene Symbol: GRIA2
GRIA2
0.720 Biomarker disease RGD CaMKII-dependent dendrite ramification and spine generation promote spatial training-induced memory improvement in a rat model of sporadic Alzheimer's disease. 25457025 2015
Entrez Id: 2891
Gene Symbol: GRIA2
GRIA2
0.720 Biomarker disease CTD_human However, GluR2 mRNAs bearing the long 3'-UTRs were shifted from untranslating mRNP complexes to ribosome-containing complexes after SE, pointing to a selective translational derepression of GluR2 mRNA mediated by the long 3'UTR. 19222700 2009
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE We also detected the expression of interleukin-1 receptor-associated protein kinases-1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6) and nuclear factor-kappaB (NF-κB) p65 using Western blotting and immunohistochemistry, which indicated the expression of IRAK1, TRAF6 and NF-κB p-p65/p65 increased in the brain of SE rats, and overexpression of miR-146a-5p could downregulate the expression of IRAK1, TRAF6, NF-κB p-p65/p65 and P-gp. 31061316 2019
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE FTY720 alleviated the overexpression of hippocampal P-gp in SE rats and reduced NF-κB activity and TNF-α and COX-2 expression, and W146 blocked the effects of FTY720. 29380527 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 Biomarker disease BEFREE H19 overexpression induced the activation of astrocytes and microglia and the release of proinflammatory cytokines (interleukin-1β and interleukin-6 and tumor necrosis factor-α) in the hippocampus, whereas H19 knockdown inhibited status epilepticus-induced glial cell activation. 29636074 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE The present pilot study aims to investigate whether liraglutide alleviates the chronic inflammation response and mitochondrial stress induced by SE in the lithium-pilocarpine animal model.We found that treatment with 25nmol/kg. i.p. once-daily after the induction of SE for 7 days reduced chronic inflammation as shown by reduced numbers of activated microglia and astrocytes, and reduced levels of TNF-α and IL-1ß in the hippocampus. 29549796 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE Rifampicin pretreatment attenuated SE-induced neuroinflammation and decreased the hippocampal expression of interleukin-1β, tumor necrosis factor-α, nuclear factor kappa-B, and cyclooxygenase-2. 30195730 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE Here, we found that TNF-α secretion and miR-155 expression levels were correlated after SE. 30006293 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE The impact of TLR3 deficiency on SE was assessed using separate cohorts of mice regarding EEG activity, seizure progression, hippocampal microglial distribution, and expression of the proinflammatory cytokines tumor necrosis factor (TNF)α and interferon (IFN)β. 28166388 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE It is widely known that SE triggers time-dependent microglial expression of pro-inflammatory cytokines that include TNFα and IL-1β. 29326654 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 AlteredExpression disease BEFREE In this study, we investigated the dynamic expression patterns of tumor necrosis factor alpha (TNF-α) and microRNA-155 (miR-155) in the hippocampi of an immature rat model of status epilepticus (SE) and children with MTLE. 23636891 2013
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 Biomarker disease RGD The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations. 20649973 2010
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.590 Biomarker disease CTD_human Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. 18455351 2008
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Biomarker disease BEFREE Moreover, perampanel treatment led to reduced SE-induced caspase-3 activation in the hippocampal lysates. 30039334 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 AlteredExpression disease BEFREE In addition, resveratrol reduced activated caspase-3 activity and attenuated neuronal cell damage in the hippocampus following status epilepticus. 30823590 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 AlteredExpression disease BEFREE BoNT/A could suppress the expression of Caspase-3 and Bax, attenuate the decrease of Bcl-2, and inhibit hippocampal neuron death induced by SE. 30877518 2019
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 AlteredExpression disease BEFREE In conclusion, TH reduced neuroinflammation and caspase-3 activity after kainic acid- (KA-) induced status epilepticus. 30108663 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Biomarker disease BEFREE These findings suggest that SE-induced aberrant mitochondrial dynamics may be involved in translocation of active caspase-3 and HMGB1 into mitochondria, which regulate neuronal apoptosis and necrosis, respectively. 30233331 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Biomarker disease BEFREE Although KA did not induce neuronal death, this study provides morphological and biochemical evidence that status epilepticus induced by KA activates caspase-3 in mossy fibers and induces autophagy in the C57BL/6 hippocampus. 28685385 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 AlteredExpression disease BEFREE Moreover, rifampicin mitigated SE-induced neuronal apoptosis as indicated by fewer positive cytochrome c immunostained cells and lower caspase-3 activity in the hippocampus. 30195730 2018
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Therapeutic disease RGD The aim of this study was to investigate the effect of gamma-Glutamylcysteine Ethyl Ester (GCEE) on the levels of GSH, caspase-3 activity, DNA damage and the expressions of Bcl-2, Bax and p53 mRNAs in rat hippocampus after status epilepticus (SE) induced by systemic kainic acid (KA). 20214503 2010
Entrez Id: 836
Gene Symbol: CASP3
CASP3
0.570 Biomarker disease CTD_human Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus. 18571097 2008