Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
0.090 Biomarker disease BEFREE Hence, PACAP systems may represent an axis on which stress and experience-driven neurotransmission converge to alter emotional memory, and mediate pathologies that are characteristic of psychiatric illnesses such as post-traumatic stress disorder. 30458282 2019
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
0.090 Biomarker disease BEFREE A genetic polymorphism within the gene encoding the pituitary adenylate cyclase- activating polypeptide (PACAP) receptor type I (PAC1R) has recently been associated with hyper-reactivity to threat-related cues in women, but not men, with post-traumatic stress disorder (PTSD). 29353055 2018
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
0.090 Biomarker disease BEFREE Recent studies point to the potential role of the (pituitary) adenylate cyclase activating polypeptide receptor 1 (ADCYAP1R1) gene, which has been implicated in stress response, in posttraumatic stress disorder (PTSD). 28746747 2017
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
0.090 AlteredExpression disease BEFREE Pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1) and its cognate PAC1 receptor (Adcyap1r1) are expressed in peripheral nociceptive pathways, participate in anxiety-related responses and have been have been linked to posttraumatic stress disorder and other mental health afflictions. 28057459 2017
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
0.090 GeneticVariation disease BEFREE Association with a single nucleotide polymorphism (rs2267735) in the gene ADCYAP1R1 encoding the type I receptor (PAC1-R) of the pituitary adenylate cyclase activating polypeptide has been reported with PTSD in female patients. 25680674 2015
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
0.090 Biomarker disease BEFREE In aggregate, these results are consistent with data suggesting that PACAP dysregulation is associated with posttraumatic stress disorder in humans. 25636177 2015
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
0.090 Biomarker disease BEFREE Analyses focused on the amygdala and hippocampus, regions that play central roles in the pathophysiology of PTSD and are known to have high densities of PACAP receptors. 24516127 2014
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
0.090 AlteredExpression disease BEFREE For example, a duplication of chromosome 7q36.3 (encoding the VPAC2 receptor) was shown to be associated with schizophrenia, and high levels of PACAP-PAC1 signaling are associated with posttraumatic stress disorder. 24220567 2013
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1
0.090 Biomarker disease BEFREE These data suggest that perturbations in the PACAP-PAC1 pathway are involved in abnormal stress responses underlying PTSD. 21350482 2011