Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD. 31622603 2020
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE Reduced levels of NPY are reported in Post-Traumatic Stress Disorder (PTSD) patients, and NPY has been proposed as a potential therapeutic target for PTSD. 31708112 2020
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 GeneticVariation disease BEFREE Several promising genes, such as the COMT (catechol-O-methyltransferase) gene, the serotonin transporter gene (SLC6A4), and neuropeptide Y (NPY) suggest gene × environment interaction between genetic variants, childhood adversity, and the occurrence of PTSD and MDD, indicating an impact of these genes on resilience. 31583809 2020
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE Intranasal neuropeptide Y (NPY) administration was shown to prevent hyperarousal in single prolonged stress (SPS) rodent PTSD model. 31250475 2019
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE The aim of this study was to investigate the association between NPY and BDNF and PTSD in individuals who experienced war-related trauma in the South Eastern Europe (SEE) conflicts (1991-1999). 31291230 2019
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE The results indicate that while SPS could be an appropriate PTSD model for females, sex differences, such as response to NPY, are important to consider. 30804766 2019
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE Neuropeptide Y is a peptide neuromodulator with protective roles including anxiolytic and antidepressant-like effects in animal models of depression and post-traumatic stress disorder. 31082535 2019
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE Additionally, other neuroendocrinological systems have been studied in PTSD including the use of oxytocin for PTSD prevention and augmentation to psychotherapy, allopregnanolone, and neuropeptide Y (NPY) for PTSD treatment. 30502374 2019
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE We examined the tolerability and anxiolytic efficacy of neuropeptide Y administered via an intranasal route in patients with posttraumatic stress disorder. 29186416 2018
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE Cardiovascular responses to intranasal neuropeptide Y in single prolonged stress rodent model of post-traumatic stress disorder. 29169656 2018
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE Knowledge of shared underlying NPY system-related neurobiological factors that contribute to the comorbidity of PTSD and gastrointestinal disorders may help guide research, development and prescription of targeted and more effective individualized therapeutic interventions. 27898588 2017
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 AlteredExpression disease BEFREE Neuropeptide Y (NPY) has robust anxiolytic properties, and its levels are reduced in patients with post-traumatic stress disorder. 28053027 2017
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE In the current article, we review the evidence base for targeting the NPY system as a therapeutic approach in PTSD, and consider impediments and potential solutions to therapeutic development. 27913193 2017
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease BEFREE We also link specific symptoms of human PTSD with extant findings in the NPY field to reveal potential physiological contributions of the neuropeptide to the disorder. 22801411 2013
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 GeneticVariation disease BEFREE The following review examines the biology of the NPY and neuroactive steroid systems as physiological links between metabolic syndrome and PTSD, a paradigmatic neuropsychiatric stress disorder. 20881319 2010
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.100 Biomarker disease LHGDN NPY and extreme stress: lessons learned from posttraumatic stress disorder. 16383009 2006