Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.340 Biomarker phenotype CTD_human Aorta mRNA expression for biomarkers of oxidative stress (HO-1, LOX-1), inflammation (MIP-2), and thrombosis (tPA, PAI-1, vWf) were increased at baseline in SH and SHHF relative to WKY. 22352330 2012
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.340 GeneticVariation phenotype LHGDN The 4G allele is associated with higher levels of PAI-1, and might increase the risk for intravascular thrombosis. 17949795 2008
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.340 GeneticVariation phenotype LHGDN Among the eight PTFEG patients with thrombosis, seven were PAI 4G/5G. 18609532 2008
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.340 Biomarker phenotype LHGDN The data collected from this population-based study demonstrate significant sex differences in PAI-1 and critical factors that may influence risk of thrombosis. 17985503 2007
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.340 GeneticVariation phenotype LHGDN PAI-1 gene 4G/5G genotype: A risk factor for thrombosis in vessels of internal organs. 12353306 2002
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.340 Biomarker phenotype CTD_human Well characterized atheroprotective mechanisms include inhibition of thrombosis (increased tissue-type plasminogen activator and decreased plasminogen activator inhibitor-1), inhibition of endothelial cell apoptosis, limitation of permeability (uptake of low-density lipoprotein), prevention of white blood cell binding and transmigration (no expression of adhesion molecules such as intercellular adhesion molecule-1 [ICAM-1] and vascular cell adhesion molecule-1 [VCAM-1] and no release of monocyte chemotactic protein-1) and increased bioavailability of nitric oxide (because of increased expression of endothelial nitric oxide synthase and manganese superoxide dismutase). 12677255 2002