Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE Thyroid neoplasms with PD-L1 expression also ae enriched with BRAF V600E mutations, suggesting that they are associated with more aggressive behavior. 31821747 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE Hence, recent research efforts have been performed trying to explore several inhibitors of the V600E mutation-containing BRAF kinase as potential therapeutic options in thyroid cancer refractory to standard interventions. 30481266 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE We further demonstrate that upfront combined inhibition of FAK and Src synergistically inhibits growth and invasion, and induces apoptosis in a panel of BRAF- and RAS-mutant thyroid cancer cell lines. 30531837 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 Biomarker disease CTD_human A Toxicogenomic Approach Reveals a Novel Gene Regulatory Network Active in In Vitro and In Vivo Models of Thyroid Carcinogenesis. 30621213 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 AlteredExpression disease BEFREE The mixed expression of BRAF under varying levels of differentiation may explain, in part, the contradictory studies regarding the impact of BRAF mutations on patient prognosis and also indicates a complex genomic signature for dedifferentiated thyroid cancer. 31229486 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE Patients with RAIR, BRAF mutant thyroid cancer. 30256977 2019
Entrez Id: 5979
Gene Symbol: RET
RET
0.700 Biomarker disease BEFREE It was originally identified in chimeric genes caused by chromosomal translocation involving RET proto-oncogene in some thyroid tumors. 30909182 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 Biomarker disease BEFREE Combination strategies involving immune checkpoint inhibitors (ICIs) with tyrosine kinase (TK) or serine/threonine protein kinase B-raf (BRAF) inhibitors are showing considerable promise in the treatment of advanced thyroid cancer. 31412566 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE Furthermore, glycolysis-related enzymes, such as LDHA and PKM2, were upregulated in BRAF V600E mutant thyroid cancer specimens, thereby promoting glycolysis. 30768848 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE Although most of the US Food and Drug Administration (FDA)-approved drugs are antiangiogenic multikinase inhibitors-vandetanib, cabozantinib, sorafenib, lenvatinib-there are two FDA indications that are mutation specific-dabrafenib/trametinib for BRAF-mutated anaplastic thyroid cancer and larotrectinib for NTRK-fusion thyroid cancer. 31322645 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 Biomarker disease BEFREE BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives. 31540406 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 Biomarker disease CTD_human Effects of curcumin and its adjuvant on TPC1 thyroid cell line. 30935902 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 Biomarker disease BEFREE Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness. 30398411 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 AlteredExpression disease BEFREE BRAF-targeted paired box gene-8 (PAX8), a thyroid-specific transcription factor, generally dysregulated in BRAF-mutated thyroid cancer. 30760304 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 AlteredExpression disease BEFREE In conclusion, the results of the current study suggest that BRAF<sup>V600E</sup>-induced KRT19 expression may promote thyroid cancer metastasis via EMT. 31289571 2019
Entrez Id: 5979
Gene Symbol: RET
RET
0.700 Biomarker disease BEFREE This includes frequently reported gene fusions such as CCDC6/RET (PTC1), PRKAR1A/RET (PTC2) and ETV6/NTRK3 , and gene fusions that are less common in thyroid cancer (TPM3/NTRK1, EML4/ALK and EML4/NTRK3). 30668525 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 Biomarker disease BEFREE BRAFi inhibited ERK signaling in BRAF<sup>V600E</sup> mutants, but not BRAF wild-type thyroid cancer cell lines. 31097454 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE This study explores the possibility of building AI models without precise pixel-level annotation in prediction of the tumor size, extrathyroidal extension, lymph node metastasis, cancer stage and BRAF mutation in thyroid cancer diagnosis, providing the patients' background information, histopathological and immunohistochemical tissue images. 29293907 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE The identification of BRAF mutations in thyroid cancer has prognostic and therapeutic implications. 29579361 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE A selective inhibitor of BRAF V600E has been proposed as a novel treatment for patients with thyroid cancer exhibiting BRAF V600E mutations. 29616135 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.700 Biomarker disease BEFREE While RET TK inhibitors (TKIs) are used to treat thyroid cancer and are in clinical trials for RET fusion-positive non-small cell lung cancer, the impact of mutations in the RET kinase domain on drug sensitivity is largely uncharacterized. 29908090 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.700 GeneticVariation disease BEFREE <i>In vivo</i>, BLU-667 potently inhibited growth of NSCLC and thyroid cancer xenografts driven by various <i>RET</i> mutations and fusions without inhibiting VEGFR2. 29657135 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 Biomarker disease BEFREE It was revealed that BRAF<sup>V600E</sup> was present in ~34% of thyroid cancer cases and was associated with age, clinical tumor stage and lymph node stage. 29805692 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE According to the literature, our data provide evidence of the BRAF and RAS roles in thyroid tumorigenesis, supporting an association between BRAF (V600E) mutations and the more aggressive clinical and pathological features of thyroid tumors. 29435002 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.700 GeneticVariation disease BEFREE In this study, we evaluated BRAF mutation in 95 Indian thyroid tumors by pyrosequencing assay. 30414980 2018