Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 Biomarker disease CTD_human The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings. 28472521 2018
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 Biomarker disease BEFREE We confirmed the association between variants within genes that code nicotinic-acetylcholine receptors (-A3, -A5 and -B3), CYP2A6/B6 and tobacco dependence development in the Czech population. 28069549 2017
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 GeneticVariation disease BEFREE Cox's proportional hazards models compared the risk of ICD-10 tobacco dependence acquisition (score 3+) for CYP2A6 and CYP2B6 metabolism groups. 26644138 2016
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 Biomarker disease CTD_human Cox's proportional hazards models compared the risk of ICD-10 tobacco dependence acquisition (score 3+) for CYP2A6 and CYP2B6 metabolism groups. 26644138 2016
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 Biomarker disease BEFREE No significant difference of tobacco dependence between normal and reduced metabolizers of CYP2A6 gene was found (FEM: SMD = 0.185, 95%CI = -0.001 to 0.371). 25683822 2015
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 Biomarker disease CTD_human CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people. 22569203 2012
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 AlteredExpression disease BEFREE Conversion to TD and TD status were associated with the intensity of recent (that is, past 3-month) cigarette consumption (adjusted incidence rate ratio (aIRR) 1.63 (95% confidence interval (CI) 1.36 to 1.97) and adjusted prevalence odds ratio (aPOR) 1.35 (95% CI 1.23 to 2.48) per 100 cigarettes per month), slowest CYP2A6 activity (aIRR 4.19 (95% CI 1.38 to 12.76) and aPOR 2.30 (95% CI 1.29 to 4.09)), depression score (aIRR 1.61 (95% CI 1.17 to 2.21) and aPOR 1.47 (95% CI 1.22, 1.75) per 1-unit change). 16728750 2006
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 Biomarker disease CTD_human Smoking cessation program and CYP2A6 polymorphism. 16720336 2006
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 Biomarker disease BEFREE Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers. 15564629 2004
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 Biomarker disease CTD_human Genetically decreased CYP2A6 and the risk of tobacco dependence: a prospective study of novice smokers. 15564629 2004
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 GeneticVariation disease BEFREE The clinical implications of CYP2A6 polymorphisms have been linked to a decreased risk of tobacco dependence, a decrease in number of cigarettes smoked and reduced risk of tobacco-related cancers. 12818518 2003
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 GeneticVariation disease BEFREE Recent data have suggested that CYP2A6 genetic polymorphisms might play a role in tobacco dependence and consumption as well as in lung cancer risk. 11207029 2001
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6
0.380 GeneticVariation disease BEFREE Functional variants at CYP2A6: new genotyping methods, population genetics, and relevance to studies of tobacco dependence. 11054771 2000
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
0.330 Biomarker disease CTD_human The Value of Biosamples in Smoking Cessation Trials: A Review of Genetic, Metabolomic, and Epigenetic Findings. 28472521 2018
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
0.330 Biomarker disease BEFREE SNPs within CHRNA5-A3-B4 and CYP2A6/B6 are associated with smoking dependence but not with tobacco dependence treatment outcomes in the Czech population. 28069549 2017
Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
0.330 GeneticVariation disease BEFREE Second, genetic variation that modifies noxious responses to nicotine and thereby influences vulnerability to tobacco dependence, in particular variation in the CHRNA5-CHRNA3-CHRNB4 nicotinic acetylcholine receptor (nAChR) subunit gene cluster, will be discussed. 24055497 2014
Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
0.330 GeneticVariation disease BEFREE Indeed, genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3, and β4 nAChR subunits, respectively, has been shown to increase vulnerability to tobacco dependence and smoking-associated diseases including lung cancer. 23143843 2013
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
0.330 GeneticVariation disease BEFREE Indeed, genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3, and β4 nAChR subunits, respectively, has been shown to increase vulnerability to tobacco dependence and smoking-associated diseases including lung cancer. 23143843 2013
Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
0.330 GeneticVariation disease BEFREE Recent human genetic studies also imply that tobacco dependence is affected by polymorphisms in the alpha3/alpha5 subunits of the nAChR (CHRNA3/CHRNA5) gene cluster. 20393456 2010
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
0.330 GeneticVariation disease BEFREE Recent human genetic studies also imply that tobacco dependence is affected by polymorphisms in the alpha3/alpha5 subunits of the nAChR (CHRNA3/CHRNA5) gene cluster. 20393456 2010
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
0.330 Biomarker disease CTD_human Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. 18414406 2009
Entrez Id: 1136
Gene Symbol: CHRNA3
CHRNA3
0.330 Biomarker disease CTD_human Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. 18414406 2009
Entrez Id: 1138
Gene Symbol: CHRNA5
CHRNA5
0.330 Biomarker disease CTD_human A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. 18519132 2008
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.330 Biomarker disease CTD_human Decreased brain dopamine transporters are related to cognitive deficits in HIV patients with or without cocaine abuse. 18579413 2008
Entrez Id: 1813
Gene Symbol: DRD2
DRD2
0.330 GeneticVariation disease BEFREE Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials. 16123753 2006