Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 Biomarker disease BEFREE Variations in IL-12B gene causes disruption of various activities one of them is suppression of Th1 response and is one of the characteristic features observed in patients with active tuberculosis. 28697396 2017
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 Biomarker disease BEFREE Along with prior studies demonstrating that therapy with IL-12 (the cytokine encoded in part by IL12B, associated with longer survival following MTB infection in mice deficient in CD4 T cells), our results suggest that this pathway might be an excellent target for the development of new modalities for treating TB, especially for HIV-positive individuals. 26942285 2016
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 GeneticVariation disease BEFREE IL12B 3' UTR and promoter polymorphisms have been reported to be correlated with IL-12 p40 production and have been suggested to be associated with TB (tuberculosis) susceptibility. 24365584 2014
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 GeneticVariation disease BEFREE A haplotype in interleukin 12B was nominally associated with tuberculosis (p = 0.02), but after permutation testing, done to assess the significance for the entire analysis, this was not globally significant. 20525402 2010
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 Biomarker disease LHGDN Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis. 18557702 2008
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 GeneticVariation disease BEFREE Further, +1188 polymorphism of IL-12B gene either alone or in combination with closely linked genes may regulate IL-12p40 production and may play a major role on acquired immunity to tuberculosis. 18522869 2008
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 GeneticVariation disease BEFREE Interestingly, IL12B promoter heterozygosity was associated with protection from tuberculosis in BCG-vaccinated individuals (p=0.03; OR=0.6). 17392024 2007
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 GeneticVariation disease LHGDN Subjects with TB were not only more likely to have the high-expressing IL12B promoter genotype (P= 0.01) but also more likely to have this in the same haplotype with the high expressing 3'UTR allele (P= 0.0009). 17445208 2007
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 AlteredExpression disease BEFREE Subjects with TB were not only more likely to have the high-expressing IL12B promoter genotype (P= 0.01) but also more likely to have this in the same haplotype with the high expressing 3'UTR allele (P= 0.0009). 17445208 2007
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 Biomarker disease LHGDN Association between the 1188 A/C polymorphism in the human IL12B gene and Th1-mediated infectious diseases. 16712658 2006
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 GeneticVariation disease LHGDN These findings support the association between IL12B intron 2 polymorphism and TB and between specific IL12B haplotypes and TB. 15295696 2004
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 GeneticVariation disease BEFREE These findings support the association between IL12B intron 2 polymorphism and TB and between specific IL12B haplotypes and TB. 15295696 2004
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 Biomarker disease BEFREE Our results suggest that IL-12B 3' UTR has no effect or has a negligible effect on human susceptibility to TB. 14551880 2003
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
0.100 Biomarker disease LHGDN No evidence for association between the polymorphism in the 3' untranslated region of interleukin-12B and human susceptibility to tuberculosis. 14551880 2003