Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE Tuberculosis (TB) has been linked with mannose-binding lectin and MASP-2 gene polymorphism. 31383674 2019
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE We made a minireview on the association of many candidate genes with TB based on recent research studies systematically, such as the human leukocyte antigen (HLA) gene, the solute carrier family 11 member 1 (SLC11A1) gene system, the vitamin D receptor (VDR) gene, the mannan-binding lectin (MBL) gene, the nitric oxide synthase 2A (NOS2A) gene, the speckled 110 (SP110) gene, and the P2X7 receptor (P2X7) gene. 31485302 2019
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 AlteredExpression disease BEFREE Moreover, some studies have shown that serum MBL levels were influenced by the MBL-2 gene polymorphisms and that it plays an important role in tuberculosis infection. 30999018 2019
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE The association of mannose-binding lectin gene (<i>MBL2</i>) polymorphisms with tuberculosis susceptibility was inconclusive. 30393476 2018
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE The objective of this study is to compare the frequency of TNF-alpha and MBL gene polymorphisms between patients diagnosed with tuberculosis and healthy volunteers in Turkey, and determine the association between tuberculosis and TNF-alpha gene (G308A) and MBL2 gene codon 54 polymorphisms. 28189510 2018
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE This meta-analysis suggests that MBL2 exon 1 polymorphisms may contribute to TB risk, especially in Asian populations. 30154670 2018
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker disease BEFREE Mannose-binding lectin (MBL) deficiency and tuberculosis infection in patients with ankylosing spondylitis. 28879439 2018
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE The resistant diplotype was more frequently found in the younger patients and retreatment cases with TB in MBL gene sites -221Y/X or codon 54 A/B. 28298186 2017
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE Thus, the reduced expression of functional MBL secondary to having MBL2 variants may partially mediate the increased susceptibility to TB risk. 27812036 2016
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE In conclusion, MBL2 rs1800450 and rs1800451 polymorphisms play a protective role in TB infection and reinforce their critical significance as a potential genetic marker for TB resistance. 27876780 2016
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE Both genotype GC at rs7096206 of MBL genes and genotype TC at rs2273346 and rs6695096 of MASP-2 genes were more prevalent in the TB patient group than the healthy control group (P<0.05, OR 1.393, 1.302 and 1.426 respectively). 25887173 2015
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 AlteredExpression disease BEFREE Previous data linking high MBL serum levels with TB were likely due to an acute phase response rather than a true effect on disease susceptibility. 25761428 2015
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE An association study of NRAMP1, VDR, MBL and their interaction with the susceptibility to tuberculosis in a Chinese population. 26261060 2015
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker disease BEFREE Many genes involved in tuberculosis susceptibility (e.g., NRAMP1 (SLC11A1), IFNG, NOS2A, VDR, ISG15, TACO, TLR1, TLR, IL18R1, chemokines, PADI, DUSP14, MBL, and MASP-2) have been subjected to epigenetic modification. 26559095 2015
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 AlteredExpression disease BEFREE Diplotype LXPA/HYPA, producer of high levels of MBL, was significantly more frequent in HHC than in patients (16.8% vs. 6.4%, P = 0.031) suggesting a protective role against the development of TB disease that has not been previously found. 24910008 2014
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE Genotype CG at rs7096206 of MBL genes (OR 2.02) and genotype TC at rs6695096 of MASP-2 genes (OR 1.67) were more prevalent in the TB patients than in healthy controls (p<0.05). 25312983 2014
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 AlteredExpression disease BEFREE The YA/YA diplotype, which exhibited high plasma MBL levels, was associated with protection against active TB in younger patients (mean age = 32)≦ 45 years old (odds ratio, 0.61; 95% confidence interval, 0.46-0.80). 24952212 2014
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker disease BEFREE The present study suggests that mannose-binding lectin can protect against TB or predispose the host to the disease depending on the haplotype pair of the host. 24008740 2013
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE The distribution of allele and genotype frequencies varied little among the different groups, and it was not possible to establish any clear association between the variants of the MBL2 gene and the susceptibility to or clinical profile of tuberculosis infections in the population analyzed. 23000376 2013
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE Our results indicate that MBL2 polymorphisms, especially at codon 57, could be considered as risk factors for TB development. 23524205 2013
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker disease BEFREE Polymorphisms in human leukocyte antigen (HLA), MBL2, CD209, vitamin D receptor, cytokine, chemokine and chemokine receptor genes have been shown to be associated with development of TB in HIV patients. 21943869 2012
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE We conclude that MBL 'B' allele is associated with protection against TB, but no influence was found on sputum conversion rate. 22050925 2012
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker disease BEFREE In vitro, M. africanum isolates bound recombinant human MBL more efficiently than did isolates of M. tuberculosis. 21695215 2011
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation disease BEFREE Several important candidate genes like human leucocyte antigen/alleles and non-human leucocyte antigen genes, such as cytokines and their receptors, chemokines and their receptors, pattern recognition receptors (including toll-like receptors, mannose binding lectin and the dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin), solute carrier family 11A member 1 (formerly known as natural resistance-associated macrophage protein 1) and purinergic P2X7 receptor gene polymorphisms, have been associated with differential susceptibility to TB in various ethnic populations. 20199642 2010
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 AlteredExpression disease BEFREE While this may indicate that high MBL levels protect against infection with TB, the increase was also of a degree consistent with the acute-phase reaction. 20636396 2010