Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.060 Biomarker disease BEFREE WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. 28561066 2017
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.060 Biomarker disease BEFREE The discovery that the 5'AMP-activated protein kinase (AMPK) serves to link the tumour suppressors LKB1 and the tuberous sclerosis complex and functions to slow macromolecular synthesis through attenuation of the mechanistic target of rapamycin complex 1 revealed a role for AMPK in tumour suppression. 26426570 2015
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.060 GeneticVariation disease BEFREE Because pathophysiology of several syndromes associated with benign tumors may converge on the tuberous sclerosis complex (TSC), serine/threonine kinase 11 (STK11), and mammalian target of rapamycin (mTOR) pathways, the purpose of the present paper was to investigate their roles in the development of SH. 18067639 2008
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.060 Biomarker disease BEFREE Thus, it has been demonstrated recently that the tumor suppressor LKB1 is a kinase that has a major role in phosphorylating and activating AMPK, and that another tumor suppressor, tuberous sclerosis complex 2, is phosphorylated and activated by AMPK. 15681023 2005
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.060 GeneticVariation disease LHGDN Here we show that LKB1, the gene mutated in PJS, acts as a tumor suppressor by activating TSC2, the gene mutated in TSC. 15231735 2004
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.060 GeneticVariation disease BEFREE Here we show that LKB1, the gene mutated in PJS, acts as a tumor suppressor by activating TSC2, the gene mutated in TSC. 15231735 2004
Entrez Id: 6794
Gene Symbol: STK11
STK11
0.060 GeneticVariation disease BEFREE Mutations in LKB1 cause Peutz-Jeghers syndrome (PJS), and mutations in either TSC1 or TSC2 cause tuberous sclerosis complex--two syndromes characterized by the development of hamartomas. 15261137 2004