Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder.
Plasma levels of IL-6 and INF-γ and lipid profile, including total cholesterol (TC), triglycerides (TGs), low-density lipoproteins (LDLs), and high-density lipoproteins, were measured in 60 patients meeting criteria of the fifth version of the Diagnostic and Statistical Manual of Mental Disorders for Major Depression (22 patients who attempted suicide and 38 patients who did not attempt suicide) and 30 healthy controls.
It is concluded that increased production of IL-6 and IL-1 in major depression may underlie both immune activation and the "acute" phase response in that illness, and that disorders in Hp may be related to the pathophysiology and pathogenesis of major depression.
While cross-sectional associations of inflammatory markers interleukin-6 (IL-6) and C-reactive protein with major depressive disorder are well established, evidence for longitudinal associations mostly comes from studies on depression symptoms, not diagnoses.
Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment.
Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder.