Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE It is concluded that increased production of IL-6 and IL-1 in major depression may underlie both immune activation and the "acute" phase response in that illness, and that disorders in Hp may be related to the pathophysiology and pathogenesis of major depression. 7506108 1994
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 GeneticVariation disease BEFREE Interleukin-6 genetic polymorphism and Chinese major depression. 16244501 2005
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease CTD_human Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. 18458677 2009
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease PSYGENET Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings. 21448457 2011
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder. 22832853 2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease PSYGENET Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation. 22683764 2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease PSYGENET Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder. 22832853 2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder. 23813968 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease PSYGENET Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder. 23813968 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease PSYGENET We confirmed a similar elevation of serum IL-6 in two separate cohorts of patients with treatment-resistant major depressive disorder. 25331895 2014
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder. 26556688 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE An altered peripheral IL6 response in major depressive disorder. 26804030 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE Identification of IL6 as a susceptibility gene for major depressive disorder. 27502736 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE A PubMed/Medline database search was performed using the following search terms: sirukumab; anti-IL-6; IL-6; major depressive disorder; inflammation. 27913990 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE Influence of fluvoxamine on plasma interleukin-6 or clinical improvement in patients with major depressive disorder. 28243095 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE The plasma level of IL-6 increased in patients with BD and MD. 28074937 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE Changes in interleukin-6 levels during electroconvulsive therapy may reflect the therapeutic response in major depression. 27858966 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE Major depressive disorder is a condition associated with dysregulated cytokine levels; among these, IL6. 27796193 2017
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE Higher concentration of interleukin 6 - A possible link between major depressive disorder and childhood abuse. 29626828 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE Association between increased serum interleukin-6 levels and sustained attention deficits in patients with major depressive disorder. 29415791 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 Biomarker disease BEFREE Some researchers suggested that the elevation of interleukin-6 (IL6) correlates with major depression and PTSD. 31291232 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 GeneticVariation disease BEFREE Sex difference in IL-6 modulation of cognition among Chinese individuals with major depressive disorder. 31629608 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE Plasma levels of IL-6 and INF-γ and lipid profile, including total cholesterol (TC), triglycerides (TGs), low-density lipoproteins (LDLs), and high-density lipoproteins, were measured in 60 patients meeting criteria of the fifth version of the Diagnostic and Statistical Manual of Mental Disorders for Major Depression (22 patients who attempted suicide and 38 patients who did not attempt suicide) and 30 healthy controls. 30844329 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE These gray matter volume differences between bipolar disorder and unipolar depression were negatively correlated with soluble IL-6 receptor levels. 30359810 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.600 AlteredExpression disease BEFREE The level of IL-6 was associated with sleep disturbances in patients with major depressive disorder. 31417262 2019