Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naïve major depressive disorder patients. 30822678 2019
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 Biomarker disease BEFREE The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study. 31019472 2019
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom. 30519155 2018
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase-2 (TPH2) polymorphism. 27807918 2017
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE TPH2 rs4290270 was genotyped in 165 suicide attempters and 188 suicide non-attempters diagnosed with major depressive disorder, bipolar disorder and schizophrenia. 28084537 2017
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population. 24376086 2015
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 AlteredExpression disease BEFREE Methylation of the tryptophan hydroxylase‑2 gene is associated with mRNA expression in patients with major depression with suicide attempts. 25955598 2015
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 Biomarker disease PSYGENET Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population. 24376086 2015
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 Biomarker disease PSYGENET Tryptophan hydroxylase 2 gene is associated with cognition in late-onset depression in a Chinese Han population. 26057341 2015
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE Three TPH2 polymorphisms, -703G/T (rs4570625), -473T/A (rs11178997), and 1463G/A (rs120074175), were selected based on previous findings of associations with MD. 26386440 2015
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 Biomarker disease PSYGENET Polymorphisms in the gene encoding the serotonin synthesis enzyme Tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and ADHD. 24196946 2014
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood. 23467366 2013
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 Biomarker disease MGD Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood. 23467366 2013
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 Biomarker disease PSYGENET Although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (Tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood. 23467366 2013
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 Biomarker disease PSYGENET A rare mutation in tryptophan hydroxylase 2 (Tph2), the rate limiting enzyme for 5-HT synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (R439H Tph2 KI) show 80% reduction in 5-HT synthesis and tissue levels. 23336047 2013
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE In total, 14 single nucleotide polymorphisms (SNPs) in coding regions of 10 serotonergic genes (HTR1A, HTR1B, HTR1D, HTR2A, HTR3A, HTR3C, HTR3D, HTR3E, HTR5A and TPH2) were genotyped in 308 Chinese Han patients with major depressive disorder. 21937687 2012
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE TPH2 gene polymorphisms and major depression--a meta-analysis. 22693556 2012
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE Our results suggest that TPH2 variants neither have a major role in MD, BD and schizophrenia nor in response to treatments. 21396719 2011
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 Biomarker disease BEFREE Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population. 21620479 2011
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE Effect of tryptophan hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression. 20738857 2010
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE Those who did not drink alcohol before suicide were more likely to have a diagnosis of major depressive disorder in their medical record and more often had the TT genotype of the tryptophan hydroxylase 2 gene. 19734157 2010
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE Furthermore, an increased frequency of G allele of TPH2 SNP may be associated with elevated suicidal behavior itself rather than with the diagnosis of major depression and may increase risk of suicidality, independent of diagnosis. 19162119 2009
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. 19590397 2009
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 GeneticVariation disease BEFREE Although the sample size is small, results from this study suggest that the TPH2 C2755A polymorphism may represent a population-specific risk factor for peripartum major depression and anxiety disorder, perhaps by interacting with hormones. 19588223 2009
Entrez Id: 121278
Gene Symbol: TPH2
TPH2
0.800 AlteredExpression disease BEFREE The mechanisms underlying these changes are uncertain, but increased TPH2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression. 19120094 2008