Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 Biomarker disease BEFREE Genetic variation in IL-1β, IL-2, IL-6, TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder. 26556688 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 Biomarker disease BEFREE An altered peripheral IL6 response in major depressive disorder. 26804030 2016
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 Biomarker disease PSYGENET We confirmed a similar elevation of serum IL-6 in two separate cohorts of patients with treatment-resistant major depressive disorder. 25331895 2015
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 Biomarker disease PSYGENET These results suggest that the plasma levels of IL-6 reflect the severity of MDD and that plasma IL-6 levels might be another biological-state marker for the depressive state. 23813968 2014
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 AlteredExpression disease BEFREE Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder. 23813968 2014
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 AlteredExpression disease BEFREE Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder. 22832853 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 Biomarker disease PSYGENET Patients with MDD showed smaller hippocampal volumes and increased inflammatory proteins IL-6 and CRP compared with HC. 22832853 2013
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 Biomarker disease PSYGENET Here we examined circulating concentrations of inflammatory cytokines (IFN-?, TNF-?, IL-1?, IL-6), and the acute phase protein CRP alongside plasma tryptophan, kynurenine, kynurenic acid (KYNA) and 3-hydroxyanthranilic acid (3-HAA) concentrations, and whole blood mRNA expression of IDO, kynurenine aminotransferases (KAT I and II), kynurenine-3-monooxygenase (KMO), kynureninase and SERT in patients with major depressive disorder (MDD) compared with age and sex-matched controls. 22683764 2012
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 Biomarker disease PSYGENET Leukocyte telomere length was compared between 18 unmedicated MDD subjects and 17 controls and was correlated with lifetime depression chronicity and peripheral markers of oxidation (F2-isoprostane/Vitamin C ratio) and inflammation (IL-6). 21448457 2011
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 Biomarker disease CTD_human Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. 18458677 2010
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 GeneticVariation disease BEFREE Interleukin-6 genetic polymorphism and Chinese major depression. 16244501 2006
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 Biomarker disease BEFREE Trier Social Stress Test-induced increases in IL-6 and NF-kappaB DNA-binding were greater in major depression patients with increased early life stress and independently correlated with depression severity, but not early life stress. 16946190 2006
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.570 Biomarker disease BEFREE It is concluded that increased production of IL-6 and IL-1 in major depression may underlie both immune activation and the "acute" phase response in that illness, and that disorders in Hp may be related to the pathophysiology and pathogenesis of major depression. 7506108 1994