Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE Lower numbers of CCR5-positive cells in the brain, combined with a less leaky blood-brain barrier, may be responsible for the decreased virus infection in the brain and consequently the absence of encephalitis in newborn macaques infected with SIV. 31119711 2019
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE Host immunogenetics in tick-borne encephalitis virus infection-The CCR5 crossroad. 30879988 2019
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE Recent evidence demonstrates that CCR5 and CCR5Δ32 are involved in the pathogenesis of other viral infections besides HIV infection. 31837381 2019
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE Chemokine receptors such as CCR5, which play roles in inflammation, immunity and viral infection, are sulfated on tyrosine residues in their extracellular N-termini. 30381052 2018
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE Both CCR5 and CXCR4 are important chemokine receptors and take vital role in migration, development and distribution of T cells, however, whether they will influence the process of T cell infiltration into bursa of Fabricius during infectious bursal disease virus (IBDV) infection is unclear. 28351707 2017
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE Understanding the mechanism of CCR5 regulation is essential for many inflammatory disorders, tumorigenesis and viral infection such as HIV. 29283386 2017
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE The use of monoclonal Abs to CCR5 with particular characteristics and mode of action may represent a novel mode to fight viral infection in either vaccinal or therapeutic strategies. 29163468 2017
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 GeneticVariation group BEFREE Data for small cohorts of influenza-infected patients are contradictory regarding the potential role of chemokine receptor 5 deficiency (CCR5-Δ32 mutation, a 32 bp deletion in the CCR5 gene) in the outcome of influenza virus infection. 25918237 2015
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE An alternative to lifelong ART is gene therapy that targets the CCR5 co-receptor and creates a population of genetically modified host cells that are less susceptible to viral infection. 26674113 2015
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 GeneticVariation group BEFREE In addition, examination of chemokine receptor 5 (CCR5) genotype, recently reported as involved in severe influenza virus disease, revealed that the F virus-infected patient was homozygous for the deleted form of CCR5 receptor (CCR5Δ32). 23326447 2013
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE We performed alanine-scanning of the V3 loop and selected C4 residues in the JRFL envelope and tested the capacity of the resulting mutants for CCR5 binding, cell-cell fusion, and virus infection. 17101166 2007
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE CXCR4 and CCR5 strains of HIV were inhibited though an early stage in viral infection upstream of fusion, and a lack of inhibition of vesicular stomatitis virus G protein pseudotyped HIV-1 suggested the anti-HIV activity was relatively selective. 17681018 2007
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE Stable simultaneous knock down of the HIV-1 coreceptors CCR5 and CXCR4 is a promising strategy to protect cells from both R5 macrophage tropic and X4 T cell tropic as well as dual tropic viral infections. 16109172 2005
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE Importantly, blocking CCR5 expression by siRNAs provided a substantial protection for the lymphocyte populations from CCR5-tropic HIV-1 virus infection, dropping infected cells by 3- to 7-fold; only a minimal effect on infection by a CXCR4-tropic virus was observed. 12518064 2003
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE Methadone induces CCR5 and promotes AIDS virus infection. 12023039 2002
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 AlteredExpression group BEFREE HOS.CD4/R5 cells stably transduced with this anti-CCR5 heterotrimer showed a marked reduction in the surface expression of CCR5 and a concomitant 70% reduction in macrophage-tropic viral infection. 11282007 2001
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE R5Rbz-transduced CD34+ cells differentiated normally into mature macrophages that carried CD14 and CD4 surface markers, expressed the anti-CCR5 ribozyme, and showed significant resistance to viral infection upon challenge with the HIV-1 BaL strain. 10933940 2000
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 AlteredExpression group BEFREE The viral load in maternal plasma samples was determined by a quantitative reverse transcriptase-PCR assay; co-receptor usage of maternal isolates was determined by viral infection in cells stably expressing CCR5 or CXC chemokine receptor 4 (CXCR4) co-receptors. 10985308 2000
Entrez Id: 1234
Gene Symbol: CCR5
CCR5
0.100 Biomarker group BEFREE Combination of CCR5 and CXCR4 inhibitors in therapy of human immunodeficiency virus type 1 infection: in vitro studies of mixed virus infections. 10982382 2000