Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 GeneticVariation group BEFREE Efficient engagement with the envelope glycoprotein membrane-proximal external region (MPER) results in robust blocking of viral infection by a class of broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV). 31787208 2020
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 Biomarker group BEFREE Deletion of the Env cytoplasmic tail improved the efficiency with which the SOS Env supported virus infection in a reducing environment. 30944182 2019
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 GeneticVariation group BEFREE It has been reported that HERV-W elements, including ERVWE1 (the so far only known HERV-W locus harboring a gene (env) functionally adopted by the human host to critically participate in placenta biogenesis), can become transactivated in a range of human non-placental cell-lines during exogenous virus infections. 26818262 2016
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 Biomarker group BEFREE Our report on the formation of RALBP/Env complexes and the role of this interaction in cell transformation opens up a new hypothesis for the dysregulation observed upon virus infection in sheep. 26041289 2015
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 AlteredExpression group BEFREE The present findings suggest that an exogenous influenza virus infection can transactivate ERVWE1 by increasing transcription of GCM1 and reducing H3K9me3 in this region and in other regions harboring HERV-W elements. 24478419 2014
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 Biomarker group BEFREE Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection. 23124109 2012
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 Biomarker group BEFREE While previous work suggests that HCMV envelope glycoprotein B is responsible for initiating this reaction, the signaling pathways stimulated by virus infection that lead to IRF3 phosphorylation have largely been uncharacterized. 20573816 2010
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 Biomarker group BEFREE E2 is the major envelope glycoprotein present as a homodimer on the outer surface of the virus and represents an important target for the induction of neutralizing immune response against the viral infection. 18045719 2008
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 AlteredExpression group BEFREE Our results suggest that the action of F-gp55 contributes to both early and late stages of Friend erythroleukemia and that persistence of F-gp55 expression may be required not only to initiate erythroleukemia but to also maintain erythroleukemia following Friend virus infection. 11850847 2002
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 Biomarker group BEFREE The gp41 subunit of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein plays a major role in the membrane fusion step of viral infection. 9811763 1998
Entrez Id: 30816
Gene Symbol: ERVW-1
ERVW-1
0.100 Biomarker group BEFREE When expressed on human cell lines, this molecule binds virus through direct interactions with the gp 120 viral envelope glycoprotein thus allowing virus infection to occur. 1930688 1991