Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker group BEFREE Thus, pre-transplant MBL levels would be important in predicting susceptibility to viral infections and mortality and might be considered a biomarker to be included in the pre-transplantation risk assessment. 31706269 2019
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker group BEFREE Mannose binding lectin (MBL) generally plays a protective role during viral infection, yet MBL-mediated complement activation promotes Ross River virus (RRV)-induced inflammatory tissue destruction, contributing to arthritis and myositis. 29324290 2018
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker group BEFREE In addition to activating the complement, MBL can induce cytokine production and contribute to a deleterious inflammatory response with severe A(H1N1)pdm09 virus infection. 29273833 2018
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation group BEFREE Host genetic factors such as MBL2 gene polymorphisms cause defects in the polymerization of MBL protein and result in a functional deficiency and/or in low serum levels that can influence susceptibility to various viral infections. 30482213 2018
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker group BEFREE Mannan-binding lectin (MBL) - associated serine protease 2 (MASP-2) co-activates the lectin pathway of complement in response to several viral infections. 27588826 2016
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation group BEFREE Some human gene variants reduce MBL activity thereby predisposing the host to bacterial and viral infections. 24321858 2014
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation group BEFREE Due to the role of KIR and low or deficient MBL haplotypes in viral infections, these genetic markers could be considered as indicators of a need for CMV prophylaxis at younger age and therefore increased probability of longer lifespan. 23302099 2013
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation group BEFREE To investigate the roles of inherited polymorphisms in the MBL2 gene and exposure to viral infection in the development of a range of adverse pregnancy outcomes, including birthweight  < 10th percentile (small-for-gestational age, SGA), antepartum hemorrhage (APH), pregnancy-induced hypertensive disorders (PIHD), and preterm birth (PTB). 21171930 2011
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 AlteredExpression group BEFREE In subgroup analyses occurrence of severe herpes virus infections in particular was associated with significantly lower mannose-binding lectin levels (P=0.02). 20418242 2010
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker group BEFREE Unlike several other viral envelopes to which MBL can bind, both recombinant and plasma-derived human MBL directly inhibited SARS-S-mediated viral infection. 20573835 2010
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 AlteredExpression group BEFREE In conclusion, low MBL levels pre-transplant predisposed patients to sepsis, fungal and viral infection. 19430499 2010
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation group BEFREE MBL2 gene polymorphisms have been shown to modulate susceptibility or protection in many viral diseases. 18361938 2008
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker group BEFREE Carriers of MBL gene variant alleles (MBLva) have decreased plasma concentrations of MBL and increased susceptibility to bacterial and viral infections. 18831943 2008
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation group BEFREE Genetic variants in the immunomodulatory gene mannose-binding lectin 2 (MBL2), were associated with risk, severity, and frequency of viral infections. 17380431 2007
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 GeneticVariation group BEFREE Since single-nucleotide polymorphisms (SNPs) in the gene encoding MBL (mbl2) alter the level of functional MBL, we hypothesized that mbl2 genotypes are a determinant of HBV persistence or recovery from viral infection. 15994813 2005
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.100 Biomarker group BEFREE However, this effect was specific for H9 cells since MBL did not neutralize cell line-adapted virus infection of PBMCs, HIV PI infection of the GHOST cell line, or VSV pseudotyped with HIV gp160 from cell line-derived virus or PI. 15117456 2004