Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 AlteredExpression group BEFREE We also demonstrated that 14-3-3η is essential in boosting the activation of MDA5-dependent antiviral innate immunity during viral infections. 30742689 2019
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine CXCL11 and pattern recognition receptors RIG-1 and MDA5. 30481615 2019
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 AlteredExpression group BEFREE RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of the pathogen-associated molecular patterns (PAMPs) in the form of viral double-stranded RNA (dsRNA) motifs to induce expression of type 1 interferons (IFN1) (IFNα and IFNβ) and other pro-inflammatory cytokines during the early stage of viral infection. 31379819 2019
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 GeneticVariation group BEFREE Viral infection caused translocation of hnRNPM from the nucleus to the cytoplasm. hnRNPM interacted with RIG-I and MDA5, and impaired the binding of the RLRs to viral RNA, leading to inhibition of innate antiviral response. 31433824 2019
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE We found that intracellular poly(I·C) transfection to mimic viral infection enhances the RIG-I/MDA5 (melanoma differentiation-associated gene 5)-mediated dimerization of interferon regulatory factor 3 (IRF-3). 29496994 2018
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I, melanoma-differentiation-associated gene 5 (MDA5), and LGP2, function as cytoplasmic virus sensor proteins during viral infection. 29939295 2018
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE In conclusion, pOASL suppresses CSFV replication via the MDA5-mediated type I IFN-signaling pathway.<b>IMPORTANCE</b> The host innate immune response plays an important role in mounting the initial resistance to viral infection. 28331099 2017
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 GeneticVariation group BEFREE The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity. 28553952 2017
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE For example, the protein encoded by the IFIH1 gene is associated with the function of viral infection in the immune system, which affects the survival rate of large yellow croakers. 29144398 2017
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE Melanoma differentiation-associated protein 5 (MDA5) mediates the innate immune response to viral infection. 28851763 2017
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE Critical role of RIG-I and MDA5 in early and late stages of Tulane virus infection. 28530548 2017
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE Sumoylation of the caspase recruitment domains of MDA5 and RIG-I is also required for their dephosphorylation by PP1 and activation upon viral infection. 28250012 2017
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE Knockdown or knockout of endogenous RNF123 potentiates IFN-β production triggered by SeV and EMCV, but not by the sensor of DNA viruses cGAS RNF123 associates with RIG-I and MDA5 in both endogenous and exogenous cases in a viral infection-inducible manner. 27312109 2016
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE Two cytosolic RIG-like RNA helicases, RIG-I and MDA5, are key to type I interferon (IFN) induction in response to viral infection. 26939124 2016
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) play a major role in the innate immune response against viral infections and detect patterns on viral RNA molecules that are typically absent from host RNA. 24743923 2014
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE RAVER1 was associated with MDA5 upon viral infection. 23390309 2013
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE The IFIH1 gene encodes a cytoplasmic receptor of the pattern-recognition receptors (PRRs) family that recognizes dsRNA, playing a role in the innate immune response triggered by viral infection. 24402011 2013
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 AlteredExpression group BEFREE Virus infection can initiate a type I interferon (IFN-α/β) response via activation of the cytosolic RNA sensors retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). 23536668 2013
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE IFIH1 affects several immune-related diseases, including psoriasis and chronic periodontitis, and provides a molecular link between genetic susceptibility, viral infections and immune-related diseases. 22152027 2012
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE Two RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5), are recently identified as cytoplasmic PPRs for virus infection. 21113677 2011
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 GeneticVariation group BEFREE Our findings suggest that variants in IFIH1 confer different susceptibility to diverse viral infections and provide insight into the relationship between adaptation to past infection and predisposition to autoimmunity in modern populations. 20538742 2010
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE Apart from TLRs, other PRRs such as RIG-1 and MDA-5 are also able to recognize viral infection and participate in the activation of type I interferon synthesis. 20533094 2010
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE The relative roles of the endosomal TLR3/7/8 versus the intracellular RNA helicases RIG-I and MDA5 in viral infection is much debated. 21079690 2010
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE Given that RNA helicase encoded by MDA-5 is a critical molecule involved in the innate immune defense against viruses, viral infection may play an important role in the pathogenesis of C-ADM and rapidly progressive ILD. 19565506 2009
Entrez Id: 64135
Gene Symbol: IFIH1
IFIH1
0.100 Biomarker group BEFREE RIG-I and MDA5 are cytoplasmic DEX(D/H) helicase proteins that can induce signaling in response to RNA ligands, including those from viral infections. 18411269 2008