Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease CTD_mouse Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. 29438700 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE TP53 (p53) is a tumor suppressor whose functions are lost or altered in most malignancies. p53 homozygous knockout (p53<sup>-/-</sup>) mice uniformly die of spontaneous malignancy, typically T-cell lymphoma. 29572430 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Deletion of <i>Mdm2</i> in T-cell lymphomas or sarcomas lacking p53 induced apoptosis and G<sub>2</sub> cell-cycle arrest, prolonging survival of mice with these tumors. 28576884 2017
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease CTD_human Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma. 26192917 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Our results provide evidence that ellipticine-induced apoptosis is exerted through DNA damage and does not require p53 activation in T-cell lymphoma. 24898668 2015
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE No p53 gene mutation was detected on the exon 4 - 9, and Pro/Arg SNPs on p53 codon 72 were detected in the cutaneous NK/T-cell lymphoma. 23557559 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Epstein-Barr virus-encoded miR-BART20-5p inhibits T-bet translation with secondary suppression of p53 in invasive nasal NK/T-cell lymphoma. 23608226 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 AlteredExpression disease BEFREE Cox regression test showed that p53 expression rate and international prognostic index score were statistically independent prognostic factors for NKTCL patients (p=0.002 and p=0.016, respectively). 23626008 2013
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Thymic T cell lymphoma is the most common malignancy in p53-deficient mice, making it difficult to study the role of p53 in other malignancies. 23166633 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Finally, irradiated mice reconstituted with p53 null, but not wild-type, HSPCs expressing Fbxo7 showed a statistically significant increase in the incidence of T cell lymphoma in vivo. 21695055 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Our results indicate that reduced levels of Separase act synergistically with loss of p53 in the initiation and progression of B- and T- cell lymphomas, which is aided by increased chromosomal missegregation and accumulation of genomic instability. 21799785 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Expression of the multidrug resistance protein MRP and the lung-resistance protein LRP in nasal NK/T cell lymphoma: further exploring the role of P53 and WT1 gene. 18972317 2009
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 AlteredExpression disease BEFREE Furthermore, we propose that suppression of p53 by Notch is a key mechanism underlying the initiation of T-cell lymphoma. 16103066 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Polymerase chain reaction-single strand conformation polymorphism followed by direct sequencing revealed TP53 mutations in 45.9% of B cell and 53.8% of T cell lymphomas. 16131817 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Although the incidence of thep53, N- and K-ras, and beta-catenin gene mutations is not high, p53 missense mutation has a prognostic value for aggressive course in nasal NK/T-cell lymphoma. 14745729 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease LHGDN Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China. 12824925 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Of these cases, three showed transformation to diffuse large B-cell lymphoma. p53 alteration was also associated with relapse of de novo diffuse large B-cell lymphoma and T-cell non-Hodgkin's lymphoma, as 2/5 (40%) diffuse large B-cell lymphomas and 3/9 (33%) T-cell non-Hodgkin's lymphomas with normal p53 at diagnosis showed p53 alterations at relapse. 12383214 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Mutations of p53 (exons 4 through 8), K-ras (exons 1 and 2), c-kit (exons 11 and 17), and beta-catenin genes (exon 3) in 12 cases of these diseases were analyzed by PCR single strand conformation polymorphism and then by direct sequencing. p53 gene mutations were detected in 5 of 5 cases of peripheral T-cell lymphoma, 3 (60%) of 5 cases of adult T-cell leukemia/lymphoma, and 1 of 2 cases of NK/T cell lymphoma. 11896204 2002
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 AlteredExpression disease BEFREE Finally, all lymphoblastic T-cell lymphomas (5 cases) and gammadelta hepatosplenic T-cell lymphomas (3 cases) were negative for expression of p53 and p21 proteins. 11230707 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 AlteredExpression disease BEFREE The aim of this study was to analyze the status of the p53 gene, and correlate it with the expression of p53 protein and its downstream target, the cyclin-dependent kinase inhibitor p21, in a series of 25 cases of well-characterized nasal NK/T-cell lymphoma from Mexico. 11733360 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Expression and mutations of the p53 gene were examined in the paraffin-embedded specimens of the nasal lesions from 42 Chinese (Beijing and Chengdu) and Japanese (Okinawa and Osaka) patients with nasal NK/T-cell lymphoma by the immunohistochemistry and single strand conformation polymorphism (SSCP) analysis of polymerase chain reaction (PCR) amplified products followed by direct sequencing. 10780666 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE The p63 and p73 genes are rarely mutated in human cancer, although p73 loss is observed in neuroblastoma and a subtype of T-cell lymphoma. p53, p63 and p73 appear to have overlapping and distinct functions: p53 regulates the stress response to suppress tumors; p63 is essential for ectoderm development; and p73 might regulate both the stress response and development. 10769197 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 Biomarker disease BEFREE Disrupted p53 function as predictor of treatment failure and poor prognosis in B- and T-cell non-Hodgkin's lymphoma. 10353742 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Sixty-six samples from 55 patients with primary cutaneous B cell and T cell lymphomas were analyzed for mutations in exons 5-9 of the P53 gene using polymerase chain reaction/single strand conformational polymorphism, and subsequent cloning and sequencing of genomic DNA. 10084308 1999
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.600 GeneticVariation disease BEFREE Twenty primary central nervous system lymphomas (PCNSL) from immunocompetent patients (nineteen B-cell lymphomas and one T-cell lymphoma) were investigated for genetic alterations and/or expression of the genes BCL2, CCND1, CDK4, CDKN1A, CDKN2A, MDM2, MYC, RB1, REL, and TP53. 9546285 1998