Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.500 Biomarker disease CTD_mouse Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. 12388339 2003
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.500 Biomarker disease CTD_human Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. 12388339 2003
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease BEFREE The ADAM33 (a disintegrin and metalloprotease domain-containing protein 33) gene, discovered through positional cloning, is the first to be associated with asthma and bronchial hyperresponsiveness. 21930123 2011
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease BEFREE A disintegrin and metalloprotease 33 (ADAM33)/Adam33 is a susceptibility gene for asthma and bronchial hyperresponsiveness in human beings and mice. 19665773 2009
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease BEFREE To replicate the role of ADAM33 in childhood lung function and development of BHR and asthma. 19236319 2009
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 GeneticVariation disease BEFREE A disintegrin and metalloprotease 33 (ADAM33) polymorphism is strongly associated with asthma and bronchial hyperresponsiveness. 18423563 2008
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease BEFREE ADAM33, a disintegrin and metalloproteinase 33 gene, has been identified as a risk factor for asthma and bronchial hyperresponsiveness and has been postulated as a gene for airway remodeling. 17339047 2007
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease CTD_human ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. 17061022 2007
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease BEFREE ADAM33, the first asthma candidate gene identified by positional cloning, may be associated with childhood asthma, lung function decline and bronchial hyperresponsiveness. 16784537 2006
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease BEFREE Subsequent genetic studies have now provided evidence that ADAM33 may be involved in determining lung function throughout life, associated with early life lung function as well as increased decline therapeutic intervention in asthma and future work will focus on the mechanisms by which it alters lung function and bronchial hyperresponsiveness. 15953744 2006
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 AlteredExpression disease BEFREE It has been previously suggested that ADAM33, which is a member of a gene family that encodes membrane-anchored proteins with a disintegrin and a metalloprotease domain, is primarily expressed in lung fibroblasts and bronchial smooth muscle cells and has been associated with airway remodelling and bronchial hyperresponsiveness. 16893396 2006
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 GeneticVariation disease BEFREE The ADAM33 gene has recently been identified as being a potentially important asthma candidate gene, and polymorphisms in this gene have been shown to be associated with asthma and bronchial hyperresponsiveness in Caucasian individuals from several populations. 16773130 2006
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease BEFREE Several ADAM33 protein isoforms occur in adult bronchial smooth muscle and in human embryonic bronchi and surrounding mesenchyme, strongly suggesting its importance in smooth muscle development and/or function, which could explain its genetic association with bronchial hyperresponsiveness. 15709049 2005
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 GeneticVariation disease BEFREE Polymorphic variation in ADAM33 is strongly associated with asthma and bronchial hyperresponsiveness. 14742294 2004
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease BEFREE The potential for therapeutic intervention with ADAM 33 is extremely attractive and further work will not only focus on the specific domains of ADAM 33, but also the mechanisms by which they lead to bronchial hyperreactivity. 15347848 2004
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease BEFREE The identification of ADAM33 as a major risk factor involved in the pathogenesis of BHR and airway wall remodelling provides insight into the pathogenesis of asthma and represents a novel therapeutic target. 12885268 2003
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 Biomarker disease BEFREE The human Adam33 gene is located on chromosome 20p13, a region that has been linked to asthma and bronchial hyperresponsiveness. 12768445 2003
Entrez Id: 80332
Gene Symbol: ADAM33
ADAM33
0.400 GeneticVariation disease BEFREE Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. 12110844 2002
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.380 Biomarker disease BEFREE The role of HOTAIR-induced downregulation of microRNA-126 and interleukin-13 in the development of bronchial hyperresponsiveness in neonates. 30790266 2019
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.380 Biomarker disease BEFREE IL4 and IL13 strongly influence bronchial hyperreactivity in response to allergen, airway remodeling, airway inflammation and airway smooth muscle proliferation. 26426602 2016
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.380 Biomarker disease CTD_human Augmented pulmonary responses to acute ozone exposure in obese mice: roles of TNFR2 and IL-13. 23434795 2013
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.380 Biomarker disease BEFREE IL-13 is a pivotal cytokine in allergic inflammation and bronchial hyperresponsiveness, and is known to influence leukotriene levels. 18551035 2008
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.380 GeneticVariation disease BEFREE In addition, there appears to be a synergistic effect between the TNF-alpha promoter polymorphism and an IL-13 coding region polymorphism in terms of asthma susceptibility and BHR in this population. 18341619 2008
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.380 Biomarker disease LHGDN Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma. 16236836 2005
Entrez Id: 3596
Gene Symbol: IL13
IL13
0.380 Biomarker disease BEFREE The Th2 cytokine IL-13 is increased in the airways of asthmatics and increases BHR in normal unsensitized animals. 12644720 2003