Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 Biomarker disease BEFREE Effects of combined statin and ACE inhibitor therapy on endothelial function and blood pressure in essential hypertension - a randomised double-blind, placebo controlled crossover study. 31486700 2020
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE Angiotensin I converting enzyme (ACE) gene is one of the most-studied candidate genes related to essential hypertension (EH). 29546999 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 Biomarker disease BEFREE Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers were similarly effective in decreasing blood pressure, mortality, and morbidity in essential hypertension. 30518809 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 Biomarker disease BEFREE On subgroup analysis, ACE I/D was associated with essential hypertension in patients from Sub-Saharan Africa but not in North Africa. 30763326 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 Biomarker disease BEFREE In addition, serum ACE2 (183.57 pg/ml; vs. 151.78 pg/ml; p = 0.02) and chymase (68.5 pg/ml; vs. 23.66 pg/ml; p = 0.034) were significantly higher in patients with uncontrolled EH than controlled EH in response to ACE-inhibitory therapy. 30307755 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE Association of ACE gene A2350G and I/D polymorphisms with essential hypertension in the northernmost province of China. 29172745 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 Biomarker disease BEFREE RAAS-blocking agents like angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers, have long been key components in the treatment of essential hypertension, heart failure, diabetic nephropathy, and chronic kidney disease, showing benefits well beyond blood pressure reduction. 28598381 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 Biomarker disease BEFREE To investigate how genetic polymorphisms of the renin-angiotensin-aldosterone system (RAS) influence EH control with angiotensin-converting enzyme inhibitor drugs (ACEI). 28577874 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 Biomarker disease BEFREE This meta-analysis of randomized parallel controlled trials was designed to compare the efficacy of atenolol with angiotensin-converting enzyme inhibitors (ACEIs) in changing pulse wave velocity (PWV), peripheral blood pressure and heart rate (HR) among patients with essential hypertension. 28534649 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE In females, carrying ACE D increased the risk for EH.(OR: 1.327). 26305278 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE The association of the ACE insertion/deletion (I/D) polymorphism with essential hypertension has been demonstrated by many studies. 27030424 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE The aim of the present study was to assess the potential impact of obesity, and angiotensin-converting enzyme (ACE) I/D polymorphism and endothelial nitric oxide synthase gene (NOS3) 4a/4b, G894T and -T786C variants on the essential hypertension. 26579574 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE The RAS-related ACE G2350A polymorphism is associated with the pathogenesis of EH in the Chinese Yi ethnic group. 26283679 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE Association of ACE, FABP2 and GST genes polymorphism with essential hypertension risk among a North Indian population. 25357227 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE Patients carrying the DD genotype had higher blood pressure-lowering response when treated with ACE inhibitors enalapril or lisinopril than those carrying ID and II genotypes, suggesting that the D allele may be a possible genetic marker for essential hypertension among Malay male subjects. 25002132 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471). 26335431 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 AlteredExpression disease BEFREE The up-regulation in relative expression of circulating Angiotensin converting enzyme mRNA and protein in patients with respect to controls might be correlated with high blood pressure in patients with essential hypertension. 24811208 2014
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE Among females, ACE I/D and ACE2 rs2106809 polymorphisms, while among males, ACE2 rs2106809 polymorphism and alcohol consumption are associated with essential hypertension in the study population. 24112034 2014
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE The M235T variant of the AGT is significantly associated with female hypertensives and ACE DD variant could be a risk allele for essential hypertension in south India. 24860821 2014
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE Patients with mild-to-moderate essential hypertension in the HOMED-BP trial were randomly allocated to first-line treatment with a calcium channel blocker (CCB), angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB). 24192120 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and diabetic essential hypertension in elderly population. 24354906 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE The aim of the present study was to investigate the association of the angiotensin-converting enzyme 2350 G/A polymorphism with atrial fibrillation in Han Chinese patients with essential hypertension. 24270955 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 AlteredExpression disease BEFREE The detection of circulating ACE mRNA expression by FQ-RT-PCR might be a useful method for early screening and monitoring of EH. 24098401 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 AlteredExpression disease BEFREE Single nucleotide polymorphisms of the angiotensin-converting enzyme (ACE) gene are associated with essential hypertension and increased ACE enzyme levels in Mexican individuals. 23741507 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE Individuals carrying the mutated TT of AGT, DD of ACE and CC of AT1R genotypes had an 1.67 (P = 0.032), 3.09 (P < 0.001) and 3.45 (P < 0.001)-fold increased risk of HTA. 21779803 2012