Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE It is widely known that low Vitamin D can lead to increased renal renin and angiotensin II production, consequently elevating blood pressure or development of essential hypertension (EH). 31102703 2020
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Hypertensive patients carrying the control genotype of rs2074192 (CC, OR = 2.37, 95% CI: 1.28-4.39) were associated with CAS ≥50%, while those carrying a high-EH-risk genotype of rs4240157 (OR = 2.62, 95% CI: 1.24-5.54), rs4646155 (OR = 2.44, 95% CI: 1.16-5.10), or rs4830542 (CC+CT, OR = 2.20, 95% CI: 1.03-4.69) were associated with atrial fibrillation (AF), larger left atrial diameter, and higher levels of renin-angiotensin-aldosterone system (RAAS) activation (renin and angiotensin I/II). 30542083 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE In this study, we investigate the underlying mechanisms behind PH exacerbation of periodontitis by using a bacteria-induced periodontitis model in normotensive and hypertensive (Nos3<sup>-/-</sup> ) mice treated with or without an Angiotensin II (Ang II) specific receptor 1 (AT1) antagonist, losartan. 30066953 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE <b>Aim:</b> The aim of this study was to explore the functional role of ACE insertion/deletion (I/D) polymorphism on the systemic quantity of angiotensin-converting enzyme (ACE), its homolog - ACE2, chymase and angiotensin II in EH patients with respect to achieved therapeutic blood pressure control. 30307755 2019
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Comparative Efficacy of Angiotensin II Antagonists in Essential Hypertension: Systematic Review and Network Meta-Analysis of Randomised Controlled Trials. 28807582 2018
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE RAAS-blocking agents like angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers, have long been key components in the treatment of essential hypertension, heart failure, diabetic nephropathy, and chronic kidney disease, showing benefits well beyond blood pressure reduction. 28598381 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II-induced microcirculatory changes in a model of primary hypertension. 28865157 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE None of them compared angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers with a placebo group in patients with essential hypertension, because few studies exist with this design. 28862020 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 PosttranslationalModification disease BEFREE The aim of the present study was to investigate whether methylation of the angiotensin I converting enzyme 2 (ACE2) promoter increases the risk of essential hypertension (EH). 28440441 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Inappropriate activation of the renin-angiotensin system (RAS) contributes to essential hypertension in a majority of patients, and macrophages express the type 1 (AT<sub>1</sub>) receptor for angiotensin II (Ang II). 28251313 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Our review indicates that (i) a narrow definition of EH is useful; (ii) in EH, indices of cardiovascular sympathetic activity are elevated in about 50% of cases; (iii) in EH as in normal conditions, mediators other than arterial blood pressure are the major determinants of renal sodium excretion; (iv) chronic hypertension is always associated with a shift in the pressure-natriuresis curve, but this may be an epiphenomenon; (v) plasma renin levels are useful in the analysis of EH only after metabolic standardization and then determination of the renin function line (plasma renin as a function of sodium intake); and (vi) angiotensin II-mediated hypertension is not a model of EH. 27214656 2017
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent: a systematic review. 26607294 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Role of tagged SNPs of the AGT gene in causing susceptibility to essential hypertension. 27398822 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE When subgrouped by sex, males with the t allele of REN Taq I had decreased risk for EH (OR: 0.529), and those with AGT -6G and CYP11B2 -344 C had increased risk for EH (OR: 1.498; 1.449). 26305278 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE We evaluated whether 1 year of angiotensin II receptor blockade decreases afferent arteriolar resistance (RA) and induces a sustained blood pressure (BP) reduction during a 10-year follow-up period in offspring of parents both diagnosed with essential hypertension. 27054529 2016
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471). 26335431 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Novel variants detected in AGT gene among patients with essential hypertension. 24452034 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE We found a significant association between the AGT G-217A gene polymorphism and the risk of essential hypertension (AA vs GG: OR = 2.52, 95%CI = 1.68-3.78; AA vs GA: OR = 2.26, 95%CI = 1.48-3.45; dominant model: OR = 0.38, 95%CI = 0.26-0.57; recessive model: OR = 1.20, 95%CI = 1.03-1.39). 26125750 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE Our findings suggested that the AGT polymorphisms have played a vital role in determining an individual's susceptibility to EH among the isolated population, which would be helpful for EH management in the remote mountainous region of Yunnan in China. 26391364 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE In conclusion, the results of this meta-analysis suggested that the AGT A-20C polymorphism was associated with risk of essential hypertension in Asians. 26505451 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease GENOMICS_ENGLAND Novel variants detected in AGT gene among patients with essential hypertension. 24452034 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE Elevated angiotensin II (AngII) is an important cause of essential hypertension. 26502817 2015
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 Biomarker disease BEFREE The autoantibodies against angiotensin AT1 receptors (AT1-AAs) in patients with essential hypertension exhibited an agonistic action like angiotensin II and maintained high blood pressure (BP). 24131669 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE The polymorphic angiotensinogen (AGT) gene is one of the most promising candidates for essential hypertension. 25143324 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.600 GeneticVariation disease BEFREE In the present study, we evaluated the contribution of four tagged SNPs namely, g.6635G > A, g.6506G > A, g.12840G > A, and g.13828T > C at AGT locus along with the analyses of haplotype and epistatic interactions in causing susceptibility to essential hypertension (EHT). 24490766 2014