Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 Biomarker disease BEFREE Parallel observations in gut microbiology coupled with screening of endogenous steroids as inhibitors of 11β-HSD2 have implicated particular gut bacteria in essential hypertension through the production of glycerrhetinic acid-like factors (GALFs). 28624548 2017
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 AlteredExpression disease BEFREE As 50% of patients with essential hypertension are insulin resistant and hyperinsulinemic, we hypothesized that insulin downregulates the 11beta-HSD2 activity. 25133511 2014
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 Biomarker disease BEFREE Whereas mutations or inhibition of 11βHSD2 by licorice have been clearly shown to produce a congenital or acquired syndrome of mineralocorticoid excess, the questions remaining are the extent to which subtle abnormalities in MR/11βHSD2 mechanisms may contribute to essential hypertension. 19909806 2010
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 GeneticVariation disease BEFREE Taken together, our results indicate that missense mutations in HSD11B2 do not substantially contribute to essential hypertension in Japanese. 16778331 2006
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 Biomarker disease BEFREE Analysis of the 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) in human essential hypertension. 16109323 2005
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 GeneticVariation disease BEFREE Role of HSD11B2 polymorphisms in essential hypertension and the diuretic response to thiazides. 15673310 2005
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 AlteredExpression disease BEFREE Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension. 14981055 2004
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 AlteredExpression disease BEFREE Inhibition of 11beta-HSD2 explains the mineralocorticoid excess state seen following liquorice ingestion and more subtle defects in enzyme expression might be involved in the pathogenesis of 'essential' hypertension. 12943516 2003
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 Biomarker disease BEFREE HSD11B2 does not have a strong influence on the development of essential hypertension in Black people, but weaker effects on blood pressure cannot be ruled out. 11531933 2001
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 GeneticVariation disease BEFREE To address this, the coding sequences of the 11BHSD2 gene was screened for mutations in 20 patients with primary hypertension with single strand conformation polymorphism and direct DNA sequencing techniques. 11114699 2000
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 AlteredExpression disease BEFREE Hypertension with no other characteristic signs of AME was found in the heterozygous father of a child with AME, and we described a girl with a homozygous gene mutation resulting in only a slightly reduced 11 beta HSD2 activity causing 'essential' hypertension. 10726708 2000
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 AlteredExpression disease BEFREE In normals or in subjects with essential hypertension, sensitivity of blood pressure to salt loading is correlated with activity of renal 11-HSD2, as measured by an increase in the ratio of urinary free cortisol/urinary free cortisone (UFF/UFE), and also correlated with length of a CA repeat polymorphism in the first intron of HSD11B2. 11196453 2000
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 Biomarker disease BEFREE Finally, while some studies demonstrate impaired 11beta-HSD activity in broader populations of patients with hypertension, further studies are required to clarify the role of 11beta-HSD2 in 'essential' hypertension. 10419018 1999
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 GeneticVariation disease BEFREE Our data do not suggest that variants of the 11beta-HSD2 gene contribute substantially to essential hypertension in Caucasians. 9856363 1998
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 Biomarker disease BEFREE Hypertensive populations should be screened to identify the prevalence of milder defects in 11beta-HSD2 in patients currently labeled as having "essential" hypertension. 9683587 1998
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 GeneticVariation disease BEFREE These data indicate the presence of a polymorphic marker in exon 3 of the HSD11B2 gene; this marker is associated with end-stage renal disease but not with essential hypertension in humans. 9589699 1998
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 AlteredExpression disease BEFREE Further studies are now required in order to evaluate the role of 11beta-HSD2 activity in the pathophysiology of 'essential' hypertension. 9431844 1997
Entrez Id: 3291
Gene Symbol: HSD11B2
HSD11B2
0.100 Biomarker disease BEFREE Genetic association of 11 beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) flanking microsatellites with essential hypertension in blacks. 8794836 1996