Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE The breakpoint cluster region of the MLL gene (MLLbcr) is frequently rearranged in therapy-related and infant acute leukaemia, but the destabilizing mechanism is poorly understood. 28626219 2018
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE The introduction of the tyrosine kinase inhibitors (TKI) into the treatment of patients with Ph or BCR-ABL1-positive acute lymphoblastic leukemia has revolutionized the treatment of this poor prognosis acute leukemia. 28581459 2017
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE High frequency of BTG1 deletions in patients with BCR-ABL1-positive acute leukemia. 24998463 2014
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE This study further supports the evidence that MLL breakpoints in therapy-related acute leukemia with MLL-AFF1 are clustered in the telomeric half of the breakpoint cluster region that contains topo II recognition sites. 24310817 2014
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE A case of 8p11 myeloproliferative syndrome with BCR-FGFR1 gene fusion presenting with trilineage acute leukemia/lymphoma, successfully treated by cord blood transplantation. 23171834 2013
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE We report cytogenetic, fluorescence in situ hybridization (FISH), and molecular analyses in the first reported case of an acute leukemia with two BCR-positive clones: one cell Ph-positive and all others Ph-negative. 11734316 2001
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE A procedure for in-cell amplification of the hybrid BCR-ABL mRNA by reverse transcription and polymerase chain reaction (RT-PCR) without extraction of the nucleic acids was performed directly in fixed and permeabilized cells of leukemia patients (22 patients with Ph'-positive chronic myeloid leukaemia-CML and 1 with Ph'-positive acute leukaemia-AL, as well as 7 Ph'-negative cases) and Ph'-positive human leukaemia cell lines (K562, LAMA-84, BV173). 10674911 2000
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Translocations involving a breakpoint cluster region of the MLL gene at chromosome band 11q23 are the most common molecular abnormalities in acute leukemias of infants and acute leukemias related to chemotherapy with DNA topoisomerase II inhibitors. 9639429 1998
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE We conclude that the FHIT gene and other uncharacterized tumour-suppressor genes at 3p14.2 are unlikely to be involved in the pathogenesis of acute leukaemia or progression of CML from chronic phase to blast crisis. 9744498 1998
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE In the present study, a combined method (CM) for attaining simultaneous identification of leukemic cell morphology, karyotype and immunophenotype has been evaluated in 21 patients with acute leukemia and 1 with CML in blast crisis were studied for morphology, citochemistry, immunophenotype and karyotype. 9293114 1997
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Molecular studies showed breakpoint cluster region rearrangement between exons e1 and a2 compatible with a p190(bcr/abl) breakpoint as observed in Ph-positive lymphoblastic acute leukaemia. 9233586 1997
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites. 8634439 1996
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Here we report that the MLL/11q23 breakpoints in 13/13 patients with secondary leukemia map to the same breakpoint cluster region (bcr) noted in de novo MLL/11q23 acute leukemias and the presence of in vivo topoisomerase II inhibitor-induced cleavage sites in MLL/11q23 bcr. 7643617 1995
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE The main differences relate to the presence of Ph-negative metaphases at diagnosis and the disappearance of Ph in complete remission in acute leukemia, and the localization of the chromosome breakpoints in the BCR gene, in the bcr segment in chronic leukemia and in the first intron of the BCR gene in 50% of acute leukemias. 8251902 1993
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE We studied breakpoints within the first BCR intron in 22 adult patients with Ph-positive leukaemia; 21 with AL and one with CML, which lacked rearrangements within the major bcr (M-bcr). 8435337 1993
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE The polymerase chain reaction (PCR) cannot be used to amplify the breakpoint in the chimaeric BCR-ABL gene in CML and acute leukaemias due to the large variation in the sites of breakpoint in the BCR gene (within a 5.8 kb region) and in the ABL gene (within a 150 kb region). 1317490 1992
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE We analyzed the structural alteration of the p53 gene, by Southern blotting with conventional and/or pulsed-field gel electrophoresis, in patients with Philadelphia chromosome-positive leukemia (chronic myelogenous leukemia; CML, 34 cases and acute leukemia; AL, 5 cases). 1391801 1992
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Rearrangements in the BCR gene first intron, the so-called bcr2 and bcr3 regions, were detected in two other cases, one with an acute lymphoblastic leukemia (ALL) and one with mixed acute leukemia. 1993310 1991
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Consistent involvement of the bcr gene by 9;22 breakpoints in pediatric acute leukemias. 1985699 1991
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE The group consisted of 14 patients with chronic myelogenous leukemia in blast crisis (CML-BC) and eight with Ph-positive acute leukemia (Ph + AL); these diagnoses were based on hematologic and cytogenetic features. 2143795 1990
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 Biomarker disease BEFREE Abnormalities of megakaryocyte morphology, increases in the numbers of megakaryocytes, and normal to increased platelet counts are not uncommon in patients with acute leukemia and CML-B, and are not uniquely associated with changes involving chromosome 3. 2388480 1990
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Ph1-positive, bcr-negative acute leukemias: clustering of breakpoints on chromosome 22 in the 3' end of the BCR gene first intron. 2930840 1989
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation. 2678002 1989
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE The configuration of the immunoglobulin heavy chain (IgH), T-cell receptor (TcR) beta and gamma chain regions, and the major breakpoint cluster region (M-bcr) genes were analysed in four cases of Ph' + acute leukemia (AL). 2693843 1989
Entrez Id: 613
Gene Symbol: BCR
BCR
0.100 GeneticVariation disease BEFREE DNA rearrangement and restriction fragment length polymorphism within the first BCR intron in Philadelphia-positive acute leukemia. 2569268 1989