Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE The ALL1 (also termed MLL) gene on human chromosome 11q23 was isolated by virtue of its involvement in recurrent chromosome translocations associated with acute leukemias with poor prognosis. 17726105 2007
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE The ALL-1 (also termed MLL) gene was originally isolated by virtue of its involvement in recurrent chromosome translocations associated with acute leukemias, particularly in infant and therapy-related leukemias. 17581865 2007
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 Biomarker disease BEFREE The chromosomal alterations at 11q23 that involve the mixed-lineage leukemia gene (MLL, HTRX1, HRX, ALL1) are one of the most common cytogenetic abnormalities in acute leukemia and have been associated with a poor prognosis. 17452254 2007
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE Rearrangements of the mixed-lineage leukemia gene MLL1 (MLL, HRX, ALL1), the human homologue of the Drosophila gene trithorax, are associated with aggressive acute leukemias in both children and adults. 15663355 2004
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE INI-1, a partner gene of ALL-1, is highly conserved in human acute leukemia. 12684622 2003
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE Study on ALL-1 gene alterations in Indian childhood acute leukemias: non-isotopic Southern blotting and molecular cytogenetics. 12860012 2003
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 Biomarker disease BEFREE The mixed lineage leukaemia gene, MLL (also called HRX, ALL-1) in acute leukaemia is fused to at least 16 identified partner genes that display diverse structural and biochemical properties. 10764144 2000
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 Biomarker disease BEFREE We have identified a gene, ALL1, that can fuse to many different genes in acute leukemias. 10197596 1999
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 Biomarker disease BEFREE We studied ALL1 rearrangement in 74 cases of AL before treatment by Southern blot avoiding room temperature exposure or delay in processing the samples which could produce ALL1 cleavage. 10457404 1999
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE To date, the prognostic value of ALL1 rearrangements has been clearly demonstrated for infant ALs only, whereas the clinical relevance of ALL1 rearrangements in the other leukemic subtypes needs further evaluation by future prospective studies on a larger number of patients homogeneously treated. 9592986 1998
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 Biomarker disease BEFREE Given the homology to HRX/MLL1/ALL1 at 11q23 that is dysregulated by translocations in acute leukemia, we hypothesize that dysregulation of MMSET contributes to neoplastic transformation in MM with t(4;14) translocation. 9787135 1998
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 AlteredExpression disease BEFREE The HRX gene (also called MLL, ALL-1, and Htrx) at chromosome band 11q23 is associated with specific subsets of acute leukemias through translocations that result in its fusion with a variety of heterologous partners. 9418860 1998
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 Biomarker disease BEFREE The ALL-1 gene was discovered by virtue of its involvement in human acute leukemia. 9539705 1998
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 Biomarker disease BEFREE The ALL1 gene at 11q23 is a promiscuous gene participating in chromosomal abnormalities of acute leukemias with 1 of over 30 potential partner genes. 9844603 1998
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 Biomarker disease BEFREE Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene. 9539779 1998
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE Translocations involving the HRX/ALL1 locus at chromosomal region 11q23 are among the most frequent cytogenetic abnormalities in acute leukemias. 9041173 1997
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE In summary, multiple molecular alterations were found in 6/15 (40%) infant acute leukaemias with ALL-1 rearrangements. 9029018 1997
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE Conversely, ALL1 breakpoints in region B were detected in 20 of 28 (71.5%) cases of infant AL, 8 of 24 (33%) cases of de novo AL, and 5 of 5 (100%) cases of TR AL (P = 0.002). 9230194 1997
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE In addition, our results emphasize the need for extending the analysis of ALL-1 gene status to infants with AL aged > 12 months. 7885037 1995
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 Biomarker disease BEFREE Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. 8058765 1994
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE Recent studies by ourselves and others have demonstrated breakpoint clustering in acute leukemias bearing translocations involving 11q23, and a Drosophila trithorax gene homologue (called MLL, HRX, or ALL-1) has been shown to span the 11q23 breakpoints of these translocations. 8282816 1994
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE ALL-1 partial duplication in acute leukemia. 8016145 1994
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE Rearrangements of the ALL-1 gene by reciprocal translocations involving chromosome band 11q23 are frequently associated with human acute leukemia. 8044771 1994
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 Biomarker disease BEFREE Immunophenotypic and morphocytochemical characterization of ALL-1-rearranged acute leukemia revealed prevalence of poorly differentiated B lymphoid and/or monoblastic features. 8339294 1993
Entrez Id: 100310785
Gene Symbol: ALL1
ALL1
0.100 GeneticVariation disease BEFREE Analysis of the ALL-1 genomic configuration in DNA from 15 infants with AL showed specific ALL-1 rearrangements in 12 cases (80%), including 5 with normal karyotypes. 8329709 1993