Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 Biomarker disease BEFREE Multidrug resistance (MDR1) represents a major obstacle in the chemotherapeutic treatment of acute leukemia (AL). 24804815 2014
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 Biomarker disease BEFREE These results showed the potential clinical relevance of MDR1, MRP1 and BCL-2 in adult patients with acute leukemia in the context of induction chemotherapy. 22037714 2012
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 GeneticVariation disease BEFREE Association of an MDR1 gene (C3435T) polymorphism with acute leukemia in India. 21133625 2010
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Prognostic significance of multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression in acute leukemia. 16614510 2006
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 Biomarker disease BEFREE These results suggest the efficacy of this quantitative analysis of MDR1 transcripts for the prediction of clinical drug resistance in acute leukemia. 12028995 2002
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 Biomarker disease BEFREE In this article, we review the different methods for determining MDR and, in particular, methods for determining P-gp/MDR1, with special reference to their potential importance for therapeutic strategies in human acute leukemia. 11185984 2000
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE MDR1/P-GP expression as a prognostic factor in acute leukemias. 10500774 1999
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE These results suggest that MDR1 gene expression can be used as a prognostic factor and may be helpful in determining chemotherapeutic protocol for patients with acute leukemia. 9886170 1998
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE It may be speculated that precytotoxic agents induced mdr1 and mdr3 P-gp expression in acute leukemia; however, in chronic leukemia, both P-gps were expressed independently of exposure to precytotoxic agents. 9150348 1997
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Multidrug resistance (Mdr1) gene expression in peripheral blasts from patients with acute leukemia only rarely increases during disease progression after combination chemotherapy. 8528050 1995
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Analysis of MDR1 and MDR3 multidrug resistance gene expression and amplification in consecutive samples in patients with acute leukaemias. 8574159 1995
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Multidrug resistance gene (mdr1) RNA levels in relation to P-glycoprotein content of leukemic cells from patients with acute leukemia. 8535665 1995
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Prognostic value of rhodamine-efflux and MDR-1/P-170 expression in childhood acute leukemia. 8632662 1995
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 Biomarker disease BEFREE A semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to investigate and compare transcription levels of the human multidrug resistance gene (MDR1) and the recently described multidrug resistance-associated protein (MRP) in 105 samples from patients with acute leukaemia at presentation and relapse. 7808005 1994
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 Biomarker disease BEFREE Thirteen out of 16 (81%) MDR-1 positive patients developed acute leukemia versus two of ten (20%) MDR-1 negative patients (p = 0.025). 8100604 1993
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE MDR1 gene expression may, in part, explain the responsiveness to chemotherapy in these distinct subtypes of acute leukemia. 8477061 1993
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Quantitative determination of mdr1 gene expression in leukaemic cells from patients with acute leukaemia. 1380280 1992
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Investigations of mdr1 regulation in normal hematopoietic elements has shown a pattern which corresponds to its regulation in acute leukemia, explaining the linkage of mdr1 to specific cellular phenotypes. 1283551 1992
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE These data suggest that mdr1 expression contributes to chemoresistance in acute leukemia. 1859877 1991
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Thus, P-glycoprotein expression and mdr1 gene amplification occurred infrequently not only in leukemia cells at the initial presentation but also in those at the relapsed cases and may not be a major cause of refractoriness to antileukemia drugs in adult acute leukemia. 2564311 1989