Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4299
Gene Symbol: AFF1
AFF1
0.060 GeneticVariation disease BEFREE This study further supports the evidence that MLL breakpoints in therapy-related acute leukemia with MLL-AFF1 are clustered in the telomeric half of the breakpoint cluster region that contains topo II recognition sites. 24310817 2014
Entrez Id: 4299
Gene Symbol: AFF1
AFF1
0.060 GeneticVariation disease BEFREE AF4 gene, frequently translocated with mixed-lineage leukemia (MLL) in childhood acute leukemia, encodes a putative transcriptional activator of the AF4/LAF4/FMR2 (ALF) protein family previously implicated in lymphopoiesis and Purkinje cell function in the cerebellum. 17135274 2007
Entrez Id: 4299
Gene Symbol: AFF1
AFF1
0.060 AlteredExpression disease BEFREE The AF4 protein interacts with the product of another gene, AF9, which is also fused to MLL in acute leukemias. 15269783 2004
Entrez Id: 4299
Gene Symbol: AFF1
AFF1
0.060 GeneticVariation disease BEFREE Chromosomal translocations t(4;11) are based on illegitimate recombinations between the human MLL and AF4 genes, and are associated with high-risk acute leukemias of infants and young children. 11527155 2001
Entrez Id: 4299
Gene Symbol: AFF1
AFF1
0.060 GeneticVariation disease BEFREE Acute leukemia with t(4;11)(q21,q23) translocation results from the in-frame fusion of the MLL to the AF4/FEL gene. 9808577 1998
Entrez Id: 4299
Gene Symbol: AFF1
AFF1
0.060 GeneticVariation disease BEFREE The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia. 8353274 1993