Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4928
Gene Symbol: NUP98
NUP98
0.090 Biomarker disease BEFREE NUP98-HOXD13 (NHD13) transgenic mice recapitulate human MDS in terms of peripheral blood cytopenias, dysplasia, and transformation to acute leukemia. 30346380 2018
Entrez Id: 4928
Gene Symbol: NUP98
NUP98
0.090 GeneticVariation disease BEFREE A variety of genetic alterations including MLL translocations, NUP98-fusions, NPM1 mutations, CDX deregulation, and MOZ-fusions lead to high-level HOXA9 expression in acute leukemias. 27258906 2016
Entrez Id: 4928
Gene Symbol: NUP98
NUP98
0.090 Biomarker disease BEFREE These findings clearly demonstrate a state of progressive genomic instability that increases the likelihood of a "second hit" or complimentary mutation later in the disease to trigger development of acute leukemia and underscores the mechanistic nature of how the NUP98-HoxD13 transgene induces progression of MDS to acute leukemia. 25220590 2014
Entrez Id: 4928
Gene Symbol: NUP98
NUP98
0.090 Biomarker disease BEFREE Genetically engineered mice that express a NUP98-HOXD13 (NHD13) transgene (Tg) display the phenotypic features of MDS, including cytopenias, bone marrow dysplasia, and transformation to acute leukemia. 22927245 2012
Entrez Id: 4928
Gene Symbol: NUP98
NUP98
0.090 GeneticVariation disease BEFREE Recent work has shown that FLT3 activating mutations can collaborate with a Nup98-HoxD13 mutation to induce an aggressive acute leukemia. 22643831 2012
Entrez Id: 4928
Gene Symbol: NUP98
NUP98
0.090 Biomarker disease BEFREE The formation of fusion genes between NUP98 and members of the HOX family represents a critical factor for the genesis of acute leukemia or acute transformation of chronic myeloid leukemia (CML). 16651408 2006
Entrez Id: 4928
Gene Symbol: NUP98
NUP98
0.090 Biomarker disease BEFREE Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. 16419055 2006
Entrez Id: 4928
Gene Symbol: NUP98
NUP98
0.090 Biomarker disease BEFREE NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia. 15755899 2005
Entrez Id: 4928
Gene Symbol: NUP98
NUP98
0.090 GeneticVariation disease BEFREE Progression of CML to acute leukemia (blast crisis) in humans has been associated with acquisition of secondary chromosomal translocations, including the t(7;11)(p15;p15) resulting in the NUP98/HOXA9 fusion protein. 12032333 2002