Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 Biomarker disease BEFREE Drinking problems negatively correlated with positive alcohol flushing response and inactive ALDH2 (all p-values < 0.05). 29205834 2018
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 GeneticVariation disease BEFREE The high prevalence of the ALDH2*2 and ADH1B*2 alleles in a large percentage of Asian subgroups has been studied as a potential protective factors against alcohol abuse, yet some individuals who possess these genes still engage in problematic alcohol use (Wall et al.2001). 27159808 2016
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 GeneticVariation disease BEFREE The ALDH2 genotypes consistently and strongly affected the alcohol sensitivity, drinking behavior and problem drinking in both the younger and older group. 26825972 2016
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 Biomarker disease PSYGENET Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]). 21917409 2012
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 AlteredExpression disease BEFREE Individuals who carry a low-activity ALDH2 (ALDH2*2) display high blood acetaldehyde levels after ethanol consumption, which leads to dysphoric effects, such as facial flushing, nausea, dizziness, and headache ("Asian alcohol phenotype"), which result in an aversion to alcohol and protection against alcohol abuse and alcoholism. 19251111 2009
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 Biomarker disease PSYGENET Individuals who carry a low-activity ALDH2 (ALDH2*2) display high blood acetaldehyde levels after ethanol consumption, which leads to dysphoric effects, such as facial flushing, nausea, dizziness, and headache ("Asian alcohol phenotype"), which result in an aversion to alcohol and protection against alcohol abuse and alcoholism. 19251111 2009
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 Biomarker disease PSYGENET Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. 17454860 2007
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 Biomarker disease CTD_human Acetaldehyde, polymorphisms and the cardiovascular system. 17590986 2007
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 Biomarker disease CTD_human Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. 16404797 2005
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 Biomarker disease PSYGENET The ALDH2*2 allele, detected in nearly half of the subjects, showed an overwhelming protective effect against a high level of alcohol consumption and problem drinking behavior, as determined by the Kurihama Alcoholism Screening Test (KAST). 12211622 2002
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 GeneticVariation disease BEFREE The ALDH2*2 allele, detected in nearly half of the subjects, showed an overwhelming protective effect against a high level of alcohol consumption and problem drinking behavior, as determined by the Kurihama Alcoholism Screening Test (KAST). 12211622 2002
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 Biomarker disease PSYGENET A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2-2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde upon ethanol consumption, a phenotype that greatly protects against alcohol abuse and alcoholism. 11535626 2001
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 AlteredExpression disease BEFREE A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2-2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde upon ethanol consumption, a phenotype that greatly protects against alcohol abuse and alcoholism. 11535626 2001
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 GeneticVariation disease BEFREE Relevance of both daily hassles and the ALDH2 genotype to problem drinking among Japanese male workers. 9514293 1998
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 GeneticVariation disease BEFREE On the other hand, persons with the heterozygous ALDH2*2 genotype (ALDH2*1/2*2) are at higher risk for developing alcohol abuse-related end-organ damage than those with a homozygous ALDH2*1/2*1 genotype. 9211568 1997
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 GeneticVariation disease BEFREE Although the ALDH2*2 allele had a significant inhibitory effect on alcohol consumption, hence on drinking problems, the apparent association was not confirmed between ADH2 genotype and overall drinking patterns for either males or females. 8727242 1996
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 GeneticVariation disease BEFREE In Asian populations the ALDH2-2 allele appears protective against alcohol abuse and alcoholism, but may favour alcoholic liver disease. 8974312 1994