Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 Biomarker disease RGD CYP2E1 testis expression and alcohol-mediated changes of rat spermatogenesis indices and type I collagen. 23819932 2013
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 Biomarker disease PSYGENET CYP2E1 gene promoter polymorphism -1293G>C increases the risk of essential hypertension in men with alcohol abuse. 24288753 2013
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 Biomarker disease CTD_human Induction of blood lymphocyte cytochrome P450 2E1 in early stage alcoholic liver cirrhosis. 20843640 2011
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 Biomarker disease PSYGENET Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease. 16425414 2005
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 AlteredExpression disease BEFREE Cytochrome P450 2E1 high activity polymorphism in alcohol abuse and end-organ disease. 16425414 2005
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 Biomarker disease PSYGENET Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse. 11505041 2001
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 AlteredExpression disease BEFREE To further investigate autoantibodies against cytochrome P-450s during alcohol abuse, sera of rats chronically treated with ethanol in the total enteral nutrition model and sera from alcoholics with or without alcohol liver disease and from control subjects were analyzed by enzyme-linked immunosorbent assay and Western blotting for the presence of IgG against rat and human CYP2E1, rat CYP3A1, and human CYP3A4. 9927612 1999
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 Biomarker disease PSYGENET To further investigate autoantibodies against cytochrome P-450s during alcohol abuse, sera of rats chronically treated with ethanol in the total enteral nutrition model and sera from alcoholics with or without alcohol liver disease and from control subjects were analyzed by enzyme-linked immunosorbent assay and Western blotting for the presence of IgG against rat and human CYP2E1, rat CYP3A1, and human CYP3A4. 9927612 1999
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 GeneticVariation disease BEFREE The findings indicate that Caucasians carrying the Rsa I c2 allele of the CYP2E1 gene may be at higher risk of developing ALD if they abuse alcohol. 8747406 1995
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 Biomarker disease PSYGENET The findings indicate that Caucasians carrying the Rsa I c2 allele of the CYP2E1 gene may be at higher risk of developing ALD if they abuse alcohol. 8747406 1995
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.740 AlteredExpression disease BEFREE CYP2E1 expression was not detected in fetal liver, kidney, lung, placenta (18 weeks gestational age) or liver (6 weeks gestational age) obtained at termination of pregnancy where maternal alcohol abuse had been established. 1575782 1992
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.720 Biomarker disease BEFREE When taken together with observations of potential genetic linkage between the NPY system and the human alcohol abuse disorders, NPY represents a promising target for treating problematic alcohol and drug use, and in protecting individuals from relapse during abstinence. 29056151 2017
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.720 Biomarker disease PSYGENET Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. 20554694 2010
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.720 Biomarker disease CTD_human Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role? 17572454 2007
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.720 Biomarker disease RGD Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. 15749341 2005
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.720 Biomarker disease PSYGENET Therefore, decreased function of CREB in the central nucleus of the amygdala might regulate anxiety and alcohol intake via decreased expression of NPY, and might provide a common link between anxiety and alcohol abuse disorders. 12967770 2003
Entrez Id: 4852
Gene Symbol: NPY
NPY
0.720 AlteredExpression disease BEFREE Therefore, decreased function of CREB in the central nucleus of the amygdala might regulate anxiety and alcohol intake via decreased expression of NPY, and might provide a common link between anxiety and alcohol abuse disorders. 12967770 2003
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.600 GeneticVariation disease BEFREE The primary outcomes were daily alcohol consumption, binge drinking, problem drinking (CAGE score 2+) and smoking status in relation to tagging variants within the FTO and ADH1B genes. 31055022 2019
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 Biomarker disease BEFREE Drinking problems negatively correlated with positive alcohol flushing response and inactive ALDH2 (all p-values < 0.05). 29205834 2018
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.600 Biomarker disease BEFREE As there was a substantial amount of subjects with alcohol abuse between both groups of patients, ADH1B is unlikely to affect the susceptibility to methanol poisoning. 29968299 2018
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.600 GeneticVariation disease BEFREE Certain ADH1B alleles have large effects on alcohol metabolism, and this relationship particularly encourages further investigations in relation to alcoholism and alcohol-associated cancer to understand better the mechanisms by which alcohol metabolism contributes to alcohol abuse and carcinogenesis. 28349588 2018
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 GeneticVariation disease BEFREE The high prevalence of the ALDH2*2 and ADH1B*2 alleles in a large percentage of Asian subgroups has been studied as a potential protective factors against alcohol abuse, yet some individuals who possess these genes still engage in problematic alcohol use (Wall et al.2001). 27159808 2016
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.600 GeneticVariation disease BEFREE The ADH1B*1/*1 genotype tended to be positively associated with problem drinking in the older group (P = 0.080) but not in the younger group. 26825972 2016
Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
0.600 GeneticVariation disease BEFREE The ALDH2 genotypes consistently and strongly affected the alcohol sensitivity, drinking behavior and problem drinking in both the younger and older group. 26825972 2016
Entrez Id: 125
Gene Symbol: ADH1B
ADH1B
0.600 GeneticVariation disease BEFREE The high prevalence of the ALDH2*2 and ADH1B*2 alleles in a large percentage of Asian subgroups has been studied as a potential protective factors against alcohol abuse, yet some individuals who possess these genes still engage in problematic alcohol use (Wall et al.2001). 27159808 2016