Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE The association of ACE gene insertion/deletion polymorphisms with LVH was assessed by chi-squared test. 31064975 2019
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 Biomarker disease BEFREE Hydrochlorothiazide and alternative diuretics versus renin-angiotensin system inhibitors for the regression of left ventricular hypertrophy: a head-to-head meta-analysis. 29465713 2018
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 AlteredExpression disease BEFREE Both the activation of the renin angiotensin aldosterone system (RAAS) and elevations of circulating Fibroblast Growth Factor-23 (FGF-23) have been implicated in the pathogenesis of left ventricular hypertrophy (LVH) in chronic kidney disease. 30120363 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE This is the first evidence that loss of cardiac KLF15 in CKD induced LVH is associated with unchecked trophic and fibrotic signalling, and that ACE inhibition ameliorates loss of cardiac KLF15. 29970016 2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 AlteredExpression disease BEFREE In conclusion, Ang II and ACE1 expression in cardiac tissue was inhibited by NGN in L-NAME-treated rats, which may contribute to the inhibitory effects of NGN on left ventricular hypertrophy that is induced by pressure overload. 30112041 2018
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 GeneticVariation disease BEFREE Activation of the local renin-angiotensin system (RAS) is an independent risk factor for the development of proteinuria and left ventricular hypertrophy (LVH) more commonly seen in masked hypertensives. 30080282 2018
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 Biomarker disease BEFREE We investigated the effect of renin-angiotensin system (RAS) blockade therapy on LV hypertrophy and mortality in patients undergoing TAVI. 28986405 2018
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 GeneticVariation disease BEFREE We investigated the role of three renin-angiotensin-aldosterone system (RAAS) gene polymorphisms in the development of LVH in hypertensive patients with a diagnosis of HFpEF. 28513230 2017
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 Biomarker disease BEFREE The renin-angiotensin system (RAS) is involved in the development of left ventricular hypertrophy (LVH) by which increases cardiac morbidity and mortality. 28160636 2017
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 GeneticVariation disease BEFREE The Renin-Angiotensin System (RAS) seems to play a major role in the establishment and maintenance of LVH through the activated systemic RAS and the Intracardiac Angiotensin System (IAS). 28387895 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE Increased ACE activity explains the significant association of rs4343 and rs4291 polymorphisms with LVH in the carriers. 28513230 2017
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 GeneticVariation disease BEFREE Being a major contributor to the development of diastolic heart dysfunction, the renin angiotensin aldosterone system and its genetic variations are thought to induce LVH in hypertensive hearts apart from haemodynamic factors. 26861937 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE In patients with hypertension who develop HFpEF, the D allele of the ACE gene is probably associated with the development of LVH. 26861937 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE Angiotensin-converting enzyme insertion/deletion polymorphism, 24-h blood pressure profile and left ventricular hypertrophy in hypertensive individuals: a cross-sectional study. 26336879 2015
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE We measured leucocyte telomere length (LTL) by Southern blot and analysed ACE I/D genotypes in 1249 subjects with hypertension and left ventricular hypertrophy (LVH). 23077078 2013
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE Taken together, our results demonstrated significant association of ACE gene I/D polymorphism with LVH risk, especially in East Asians, and this association was more pronounced in studies involving males and untreated subjects. 22773337 2012
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 Biomarker disease RGD Comparison of the effects of cilnidipine and amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats. 22796710 2012
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 GeneticVariation disease BEFREE Polymorphisms of the renin-angiotensin-aldosterone system (RAAS) represent an attractive hypothesis as potential disease modifiers, as these genetic variants alter the 'activation status' of the RAAS, which leads to more left ventricular hypertrophy through different pathways. 21507890 2011
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE Also, ACE and the 12 other genotypes did not affect risk of the primary composite endpoint or its components stroke, myocardial infarction, and cardiovascular death, or treatment differences between losartan and atenolol on these endpoints, as assessed by Cox proportional hazards models including baseline Framingham risk score and LVH. 20065889 2010
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 Biomarker disease BEFREE No association was found between ACE-DD and LVH (odds ratio (OR) = 2.12, 95% confidence interval = 0.82-5.46). 19997001 2010
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE An association between the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene and the progression of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy has been reported. 20179607 2010
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 GeneticVariation disease BEFREE Myocardial fibrosis in patients with symptomatic obstructive hypertrophic cardiomyopathy: correlation with echocardiographic measurements, sarcomeric genotypes, and pro-left ventricular hypertrophy polymorphisms involving the renin-angiotensin-aldosterone system. 18835191 2009
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease LHGDN The aim of the study was to evaluate the prevalence of hypertension, left ventricular hypertrophy, hypertensive retinopathy in patients treated with haemodialysis and to evaluate the association between the polymorphism of RAAS genes: ACE I/D, AGT M235T AT1R A1166C, CYP112 (-344) and the systemic complications of arterial hypertension such as hypertensive retinopathy, left ventricular hypertrophy and also mortality in haemodialysis patients. 19112833 2008
Entrez Id: 5972
Gene Symbol: REN
REN
0.600 Biomarker disease CTD_human A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes. 18679781 2008
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.600 GeneticVariation disease BEFREE A weaker renal function dependent association between the ACE I/D polymorphism and LVH was also observed. 17903694 2007