Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE FGFR1 has been implicated in numerous cancer types including squamous cell lung cancer, a subset of non-small cell lung cancer with a dismal 5-year survival rate. 30257990 2019
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Our work therefore provides a rationale for the inhibition of MCL-1, BCL-XL, and FGFR1 to maximize therapeutic response in FGFR1-expressing lung SqCC. 29743589 2018
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Furthermore, we detected subclonal <i>NRAS</i> amplifications in 3 of 20 (15%) primary human <i>FGFR1</i>-amplified SQLC specimens. 28630215 2017
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Fibroblast growth factor receptor 1 (FGFR1) has been demonstrated to be a high-frequency targetable oncogene specific for smoking-associated lung cancers, present in over 20% of lung squamous cell carcinoma cases. 28483948 2017
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Amplification of fibroblast growth factor receptor 1 (FGFR1) is one of the most frequent targets in lung squamous cell carcinoma (SQCC). 28558758 2017
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 AlteredExpression disease BEFREE Enhancement of the anti-tumor activity of FGFR1 inhibition in squamous cell lung cancer by targeting downstream signaling involved in glucose metabolism. 29190880 2017
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE FGFR1 amplification is more prevalent in late stage SQC patients but does not predict chemotherapy response. 28008744 2017
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Frequency of FGFR1 amplification is similar in SqCC with and without lymph node metastases, but status in metastatic sites may be discordant from the primary in a small subset of cases, which may affect the decision to perform testing of metastatic SqCCs. 26712871 2016
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 GeneticVariation disease BEFREE FGFR1 CNG (10.7%), FGFR1 mutation (2.7%), FGFR2 mutation (2.7%), FGFR4 mutation (5.3%), and FGFR3 fusion (1.3%) were detected in LSCC specimens by NGS. 27581340 2016
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 AlteredExpression disease BEFREE We show that SOX2 but not FGFR1 overexpression in tracheobronchial basal cells combined with Cdkn2ab and Pten loss results in LSCC closely resembling the human counterpart. 27728803 2016
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE The aim of the present study was to evaluate FGFR1, PIK3CA and SOX2 protein expression in SQCC and determine whether the expression of these can be used as prognostic biomarkers. 25384882 2015
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE This meta-analysis strongly suggests that FGFR1 amplification occurs more frequently in male, SQCC and smokers, and it is a risk factor for poor prognosis among Asian patients with SQCC. 26788508 2015
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Eligible studies regarding incidence of FGFR1 amplification in lung SQCC and correlation between FGFR1 amplification and clinicopathological features or survival were extracted and analyzed. 25433983 2015
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 GeneticVariation disease BEFREE The purpose of this study was to elucidate if these tumors harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, which has recently been identified as a potential therapeutic target in squamous cell lung cancer. 23913758 2014
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE In this issue of Cancer Discovery, Malchers and colleagues perform a detailed characterization of 8p12 in squamous cell lung cancer and find remarkable genomic heterogeneity in this region, raising the possibility that other genes in addition to FGFR1 may play a role in squamous cell lung cancer. 24501305 2014
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Recently, the fibroblast growth factor receptor 1 (FGFR1) has been identified as the first actionable target in squamous cell lung cancer. 24584974 2014
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE However, the FGFR1 amplification patterns in SCLC differs strongly from the previously described FGFR1 amplification pattern in squamous cell carcinoma of the lung, as positive SCLC harbor mostly homogeneous high-level amplifications. 23887299 2014
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE This review focuses on the emerging role of FGFR1 as a therapeutic target in lung squamous cell carcinoma and reviews current agents that are in clinical development for the treatment of FGFR-dependent cancer. 23469973 2013
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE FGFR1 amplification is not prognostic in resected lung squamous cell carcinoma patients. 24077455 2013
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Fibroblast Growth Factor Receptor 1 (FGFR1) amplification frequently occurs in squamous cell carcinoma of the lung and represents a novel druggable therapeutic target in this and other malignancies. 23434054 2013
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE More recently oncogenic drivers, such as DDR2, FGFR1 and PI3KCA, have been characterized in squamous cell lung carcinoma (SCC) and target agents are currently under evaluation. 23930754 2013
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Recently, we characterized fibroblast growth factor receptor 1 amplification as a target for a rational therapy in lung squamous cell carcinoma. 23619603 2013
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Fibroblast growth factor receptor 1 gene amplification is associated with poor survival and cigarette smoking dosage in patients with resected squamous cell lung cancer. 23182986 2013
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE FGFR1 amplification is a common genetic event occurring at a frequency of 16% in L-SCCs. 22499828 2012
Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
0.400 Biomarker disease BEFREE Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer. 22684217 2012