×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
Biomarker
disease
BEFREE
We conducted further optimization of dual enzymatic inhibitions towards FGFR1 and DDR2 , two important kinases in lung squamous cell carcinoma .
30572178
2019
×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
GeneticVariation
disease
BEFREE
A total of 11 patients harboring a DDR2 mutation was detected among the 271 sequenced lung SCC samples (4%).
29129434
2018
×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
GeneticVariation
disease
BEFREE
Although Forced expression of DDR2 and its mutant (T681I ) led to induce SQCC cell invasion in vitro, only wild type DDR2 enhanced lung metastasis in an animal model.
28676216
2017
×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
GeneticVariation
disease
BEFREE
Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2 ) gene in squamous cell lung cancer of Chinese patients.
24885564
2014
×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
Biomarker
disease
BEFREE
In lung squamous cell carcinoma (lung SqCC), recent studies have suggested that DDR2 mutations are a biomarker for therapeutic response to dasatinib and clinical trials are underway testing this hypothesis.
24296828
2014
×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
GeneticVariation
disease
BEFREE
Ten of 215 pure SQCC s (4.7%; 95% CI, 2.3%-8.4%) harbored mutations, including seven with PIK3CA, and each with AKT1, DDR2 , and EGFR.
24158231
2014
×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
Biomarker
disease
BEFREE
More recently oncogenic drivers, such as DDR2 , FGFR1 and PI3KCA, have been characterized in squamous cell lung carcinoma (SCC) and target agents are currently under evaluation.
23930754
2013
×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
GeneticVariation
disease
CLINVAR
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.
22328973
2011
×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
GeneticVariation
disease
BEFREE
Investigators report the identification of novel somatic mutations in the DDR2 kinase gene in squamous cell carcinoma of the lung .
22586316
2011
×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
GeneticVariation
disease
BEFREE
A squamous cell lung cancer patient with a response to dasatinib and erlotinib treatment harbored a DDR2 kinase domain mutation.
22328973
2011
×
Entrez Id:
4921
Gene Symbol:
DDR2
DDR2
0.490
CausalMutation
disease
CGI