Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 GeneticVariation disease BEFREE In the remaining cohort of lung AD without these known drivers, 273 cancer-related genes were altered in at least 0.1% of cases, including STK11 (21%), NF1 (13%), MYC (9.8%), RICTOR (6.4%), PIK3CA (5.4%), CDK4 (4.3%), CCND1 (4.0%), BRCA2 (2.5%), NRAS (2.3%), BRCA1 (1.7%), MAP2K1 (1.2%), HRAS (0.7%), NTRK1 (0.7%), and NTRK3 (0.2%). 27151654 2016
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 Biomarker disease CTD_human Gene expression analysis in the lung of the rasH2 transgenic mouse at week 4 prior to induction of malignant tumor formation by urethane and N-methylolacrylamide. 26558449 2015
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 GeneticVariation disease BEFREE In this surgical series, 52 resected lung adenocarcinomas from never-smokers (< 100 cigarettes in a lifetime) at a single institution (Fudan University, Shanghai, China) were analyzed concurrently for mutations in EGFR, KRAS, NRAS, HRAS, HER2, BRAF, ALK, PIK3CA, TP53 and LKB1. 20855837 2010
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 PosttranslationalModification disease BEFREE Our results indicate a trend of inverse relationship between Kras2 activation and RASSF1A promoter methylation in the majority of human lung adenocarcinomas and large cell carcinomas. 14511407 2004
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 GeneticVariation disease BEFREE The D12S1034 locus was located 800-1350 kb proximal to the KRAS2 locus, and in the region syntenic to the core Pas1 region of approximately 1.5 Mb in size where a single haplotype is shared by several mouse-inbred strains susceptible to lung adenocarcinoma development. 12117776 2002
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 GeneticVariation disease BEFREE In the Japanese population, the KRAS2/RsaI marker was significantly associated with prognosis of lung adenocarcinoma, whereas the European study did not confirm this association. 10720740 2000
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 GeneticVariation disease BEFREE Allele-specific oligonucleotide hybridization revealed the same KRAS2/RsaI polymorphism associated with risk and prognosis as in Italian lung ADCA patients; the polymorphism was significantly associated with clinical stage (P < 0.001) and survival rate (log rank = 0.0014), confirming the mapping of PAS1 and pointing to the role of this locus in human lung cancer. 11016621 2000
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 GeneticVariation disease BEFREE Our results indicate the importance of specific activating mutations of the KRAS2 gene as genetic markers of clinical outcome for patients with lung adenocarcinoma. 9645349 1998
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 GeneticVariation disease BEFREE To clarify its biological nature, 10 samples of goblet cell-type adenocarcinoma of the lung were collected and compared with 10 other pulmonary mucin-producing adenocarcinomas with respect to immunohistochemical features and the presence of Ki-ras gene mutation in codons 12 and 13. 9234384 1997
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 GeneticVariation disease BEFREE The mapping near Kras2 of pulmonary adenoma susceptibility 1 (Pas1), a major locus affecting inherited predisposition to lung cancer in mice prompted us to test the homologous human region (12p12) for association with lung adenocarcinoma, by a population-based study. 9364000 1997
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 AlteredExpression disease BEFREE Forestomach squamous cell carcinomas, lung adenocarcinomas and spleen angiosarcomas were induced by dimethylbenzanthracene (DMBA) in the rasH2 transgenic mouse line carrying human c-Ha-ras genes with their own promoter, encoding the prototype p21 gene product. 7928625 1994
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
0.500 GeneticVariation disease BEFREE The correlation between clinicopathologic findings and point mutation in codon 12 of c-Ki-ras gene was examined in primary lung adenocarcinomas using polymerase chain reaction and oligonucleotide hybridization techniques. 2196110 1990