Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression disease BEFREE Immunohistochemistry was performed, which demonstrated that TNKS, β-catenin and Myc proto-oncogene protein (c-Myc) proteins are positively expressed in lung adenocarcinoma tissue; this expression was significantly higher than that in normal adjacent non-carcinoma tissues. 29805633 2018
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker disease CTD_human c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma. 27602772 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 GeneticVariation disease BEFREE Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas. 26833129 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression disease BEFREE CRISPR/Cas9-mediated repression or deletion of a constituent enhancer within the MYC-LASE region led to significant reductions in the expression of MYC and its target genes and to the impairment of anchorage-independent and clonogenic growth, consistent with an oncogenic function. 26656844 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker disease CTD_human CRISPR/Cas9-mediated repression or deletion of a constituent enhancer within the MYC-LASE region led to significant reductions in the expression of MYC and its target genes and to the impairment of anchorage-independent and clonogenic growth, consistent with an oncogenic function. 26656844 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker disease BEFREE The MZF1/c-MYC axis mediates lung adenocarcinoma progression caused by wild-type lkb1 loss. 24793789 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression disease BEFREE Furthermore, miR-342-3p module activity, which we defined as a gene set reflecting the experimentally substantiated influence of miR-342-3p on mRNA expression, was found to be inversely correlated with MYC activity reflected by MYC module activity in three independent datasets of lung adenocarcinoma patients obtained from the Director's Challenge Consortium of the United States (P = 1.94 × 10(-73)), the National Cancer Center of Japan (P = 9.05 × 10(-34)) and the present study (P = 1.17 × 10(-19)). 26483346 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker disease BEFREE Additional studies are required to determine if patients with lung adenocarcinoma with c-MYC gain are candidates for additional first-line treatment to mitigate their increased risk for disease progression and death. 24809777 2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 AlteredExpression disease BEFREE Epigenetic alterations at the GATA4 promoter level were observed after MYC expression in lung adenocarcinoma in vivo and in vitro. 23239811 2013
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker disease BEFREE The likely driving force behind MYC contribution to uncontrolled cell proliferation in lung adenocarcinoma is ATAD2. 22914773 2012
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker disease BEFREE MYC amplification as a prognostic marker of early-stage lung adenocarcinoma identified by whole genome copy number analysis. 21148746 2011
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker disease BEFREE Long-term disease-free survival of a patient with synchronous bilateral lung adenocarcinoma displaying different EGFR and C-MYC molecular characteristics. 22045881 2011
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 Biomarker disease BEFREE Here we used multiple mouse models of lung adenocarcinoma to identify genetic events that can cooperate with MYC activation to promote the genesis of non-small-cell lung cancer (NSCLC), the most common form of lung cancer in humans. 21406400 2011
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 GeneticVariation disease BEFREE Multiple genetic pathways defined by gains of MYC, deletions of RB1 and WRN or gains on 7p and 7q are involved in lung adenocarcinoma in never smokers. 21151896 2010
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.500 GeneticVariation disease BEFREE To examine how the MYC and K-ras(G12D) oncogenes cooperate for the initiation and maintenance of tumorigenesis, we generated double conditional transgenic tumor models of lung adenocarcinoma and lymphoma. 18461184 2008