Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Mutational status of PIK3ca oncogene in oral cancer-In the new age of PI3K inhibitors. 31831300 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Migration is regulated by EP4/PI3K/Orai1 signaling in oral cancer. 31755615 2020
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Targeted disruption of PI3K/Akt/mTOR signaling pathway, via PI3K inhibitors, promotes growth inhibitory effects in oral cancer cells. 30519710 2019
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression group BEFREE Crosstalk between Raf-MEK-ERK and PI3K-Akt-GSK3β signaling networks promotes chemoresistance, invasion/migration and stemness via expression of CD44 variants (v4 and v6) in oral cancer. 30409306 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Oridonin inhibits oral cancer growth and PI3K/Akt signaling pathway. 29432993 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer. 30352996 2018
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 GeneticVariation group BEFREE In total, 28 loci, that is, 14q32.33 (AKT1), 5q22.2 (APC), 11q22.3 (ATM), 2q33.1 (CASP8), 11q13.3 (CCND1), 16q22.1 (CDH1), 9p21.3 (CDKN2A), 1q31.1 (COX-2), 7p11.2 (EGFR), 22q13.2 (EP300), 4q35.2 (FAT1), 4q31.3 (FBXW7), 4p16.3 (FGFR3), 1p13.3 (GSTM1-GSTT1), 11q13.2 (GSTP1), 11p15.5 (H-RAS), 3p25.3 (hOGG1), 1q32.1 (IL-10), 4q13.3 (IL-8), 12p12.1 (KRAS), 12q15 (MDM2), 12q13.12 (MLL2), 9q34.3 (NOTCH1), 17p13.1 (p53), 3q26.32 (PIK3CA), 10q23.31 (PTEN), 13q14.2 (RB1), and 5q14.2 (XRCC4), were validated to be associated with oral cancer. 29037125 2017
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers. 26882569 2016
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Furthermore, this critical review provides a complete picture of the PIK3CA oncogene and its deregulation in oral cancer, which may facilitate early diagnosis and improve prognosis through personalized molecular targeted therapy in oral cancer. 23597702 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 AlteredExpression group BEFREE We observed significantly higher PI3K p110α (p<0.0001) and lower (p<0.0001) vesicular sorting protein 34p (Vps34p) mRNA both in PBMC and tissue samples of oral cancer patients as compared to the normal controls. 23228846 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE Dissecting the EGFR-PI3K-AKT pathway in oral cancer highlights the role of the EGFR variant III and its clinical relevance. 23806066 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group CTD_human Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin. 24224046 2013
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.400 Biomarker group BEFREE We also discussed how targeting the Akt and MEK, downstream effectors of the PI3K/Akt and MAPK pathways, respectively, would probably pave the possible molecular therapeutic target for the ras driven tumorigenesis in oral cancer. 22240207 2012