Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Overexpression of cyclooxygenase-2 in oral cancer increases lymph node metastasis and is associated with a poor prognosis. 28740192 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group BEFREE On the other hand, 1195 A > G (rs689466) polymorphism in COX-2 did not confer susceptibility to oral cancers. 25977924 2015
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Hypermethylation of E-cadherin and COX-2 was observed in 36% and 22% of oral cancer samples, respectively. 23250779 2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE In a previous study, we demonstrated that cyclooxygenase-2 (COX-2) is overexpressed in Korean patients having oral cancer. 19910795 2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 PosttranslationalModification group BEFREE Overexpression of the cyclooxygenase-2 gene (COX-2) is observed frequently in OPLs and oral cancers, suggesting that this gene may play an important role in the progression of oral cancer. 19197984 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE PGE2 production in oral cancer cell lines is COX-2-dependent. 19278989 2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE COX-2 expression in oral cancer was found to be independent of grade of tumor and stage of disease. 18356024 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group BEFREE Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. 18922923 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE In conclusion, this study demonstrates correlation between over expression of NF-kappaB and COX-2 in early precancerous stages of development of oral cancer and sustained elevation down the tumorigenic pathway, underscoring their potential as targets for early intervention. 17354234 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE We measured COX-1 and COX-2 m-RNA expression in samples of both oral cancer and matched oral mucosa from 22 patients by RealTime RT-PCR; clinic pathological data (grading, TNM staging, inflammation, follow-up) of all patients were available for statistical evaluation. 17624243 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Butyrate inhibits oral cancer cell proliferation and regulates expression of secretory phospholipase A2-X and COX-2. 17595767 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. 15756036 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group BEFREE Molecular targeting of COX-2, PGE(2) synthase, or PGE(2) receptors may be useful as a chemopreventive or therapeutic strategy for oral cancer. 12738747 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression group BEFREE COX-2 expression was correlated to DNA content as a genetic risk marker of oral cancer. 12747975 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation group BEFREE These data strongly indicate that COX-2 inhibitors (coxibs) should be investigated as chemopreventive agents in patients identified to be at high risk of developing oral cancer. 12542827 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker group CTD_human Elevated expression of cyclooxygenase (COX)-2 in oral squamous cell carcinoma--evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. 12969226 2003