Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker disease BEFREE Here we investigated whether and how the RUNX2/OPN axis regulates lung metastasis of osteosarcoma. 30637720 2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker disease BEFREE We show that JNK signaling enhances expression of the ECM and stem cell niche components osteopontin, also called secreted phosphoprotein 1 (SPP1), and tenascin C (TNC), that promote lung metastasis. 30190333 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker disease BEFREE Plumbagin reduces osteopontin-induced invasion through inhibiting the Rho-associated kinase signaling pathway in A549 cells and suppresses osteopontin-induced lung metastasis in BalB/c mice. 28359791 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker disease BEFREE Oppositely, tumor-originated intracellular osteopontin promoted tumor cell survival by preventing tumor-related protein 53-mediated apoptosis, while the secretory osteopontin functioned in a paracrine mode to accelerate lung metastasis by enhancing tumor-derived C-C-motif chemokine ligand 2 signaling to cognate host receptors. 28197374 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker disease BEFREE Mechanically, CD44v, but not CD44s, responds to osteopontin (OPN) in the lung environment to enhance cancer cell invasiveness and promote lung metastasis. 28300837 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker disease BEFREE Intravenous injection of recombinant OPN restored the lung metastasis of OPN-deficient 4T1 cells, suggesting that OPN functioned in a paracrine manner. 27960041 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker disease BEFREE Notably, inhibition of fibroblast osteopontin with low doses of a novel small molecule prevents lung metastasis in a mouse model of human breast cancer metastasis. 26821678 2016
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 AlteredExpression disease BEFREE The Ht2 and -443TT genotype could significantly increase the promoter transcriptional activity and expression level of OPN compared with the Ht3 or -443CC genotype, and lead to an obvious increase in both in vitro invasion and in vivo tumor growth and lung metastasis of HCC cells (P<0.05). 23079960 2013
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker disease BEFREE In mice bearing orthotopical xenografts with HCCLM6, OPN inhibition following therapeutic treatment with OPN ASO significantly decreased lung metastases although tumor weight did not appear to be reduced. 21174062 2011
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 AlteredExpression disease BEFREE Overexpression of either OPN-A or B in two different cell types promoted local tumor growth and lung metastasis in SCID mouse xenografts. 20224789 2010
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker disease BEFREE Aerosol delivery of small hairpin osteopontin blocks pulmonary metastasis of breast cancer in mice. 21203518 2010