Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
0.070 AlteredExpression disease BEFREE TSP1 mRNA level is significantly associated with the Enneking stage of osteosarcoma and lung metastasis. 29100277 2017
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
0.070 GeneticVariation disease BEFREE B-Raf(V600E) cells in which either B-Raf(V600E) or TSP-1 were knocked down were implanted orthotopically into the thyroids of immunocompromised mice, resulting in significant reduction in tumor size and fewer pulmonary metastases from the primary carcinoma as compared with the control cells. 20498063 2010
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
0.070 Biomarker disease BEFREE To confirm that lack of cleavage of TSP1 ablated its antiangiogenic function in the lung, we generated colon cancer cells stably secreting only the 3TSR domain and found that they inhibited formation of both liver and lung metastases. 20103648 2010
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
0.070 Biomarker disease BEFREE In this study, we exploited S. choleraesuis carrying thrombospondin-1 (TSP-1) gene for treating primary melanoma and experimental pulmonary metastasis in the syngeneic murine B16F10 melanoma model. 15375381 2005
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
0.070 AlteredExpression disease BEFREE In the present study, we found that epidermal growth factor (EGF) up-regulated TSP-1 expression in FTC-133 (primary tumor) but not in FTC-238 (lung metastasis) thyroid cancer cells. 15707585 2005
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
0.070 AlteredExpression disease BEFREE Our laboratory previously showed that the CSVTCG (cys-ser-val-thr-cys-gly) sequence of TSP-1 functioned as a tumor cell adhesion domain and CSVTCG peptides as well as an anti-peptide antibody possessed anti-metastatic activity in a murine model of lung metastasis. 15095410 2004
Entrez Id: 7057
Gene Symbol: THBS1
THBS1
0.070 Biomarker disease BEFREE Injection of transfected clones that overexpressed TSP1 into the mammary fat pad of nude mice resulted in a dose-dependent inhibition of primary tumor size and an inhibition of spontaneous pulmonary metastases, which occurred in 21-30% of THBS-1 transfectants compared to 44-49% of controls (P = 0.007). 7527299 1994