Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 GeneticVariation disease BEFREE Depletion of IL-6 via combined deletion of Il6 and Gprc5a genes almost completely eliminated lung metastasis in Gprc5a-ko/Il-6-ko (5a-/-;Il6-/-) mice. 31848193 2020
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 AlteredExpression disease BEFREE Increased expression of CD44s predicted poor event-free survival and local recurrence and was observed in myxofibrosarcoma patients with lung metastasis. 31662543 2020
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 Biomarker disease BEFREE These LLCm1A cells showed increased production of matrix metalloproteinases (MMPs), including MMP-2, -3, -9, and -13, and pulmonary metastasis following injection into mouse tail veins. 31489536 2020
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 AlteredExpression disease BEFREE Using a mouse xenograft model, we found that Proscillaridin A treatment significantly inhibited tumor growth and lung metastasis in vivo and decreased the expression levels of Bcl-xl and MMP2. 31708095 2020
Entrez Id: 7431
Gene Symbol: VIM
VIM
0.100 Biomarker disease BEFREE GLS2 was linked to enhanced in vitro cell migration and invasion, mesenchymal markers (through the ERK-ZEB1-vimentin axis under certain conditions) and in vivo lung metastasis. 31541193 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE Left-sided tumors with wild-type KRAS had greater proportion of liver metastasis (78.6% versus 53.5%, P = 0.00), whereas those with mutant KRAS had greater proportion of lung metastasis (23.3% versus 8.7%, P = 0.02). 30737098 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation disease BEFREE KRAS mutation was detected in 23/45 cases using ct-DNA (liver or lung metastasis, 18/19; mutation allele frequency [MAF], 0.1-31.7%; peritoneal metastasis, 3/9 [0.1%], locally advanced, 2/17 [0.1-0.2%]). 31746520 2020
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE The mRNA level of stromal cell-derived factor-1 (SDF-1) in the lung and the number of accumulated SDF-1-expressing CD11b<sup>+</sup>Gr1<sup>+</sup> MDSCs were elevated at an early stage in lung metastasis of C-X-C chemokine receptor type 4 (CXCR4)-expressing RM9 in an mPGES-1-dependent manner. 31715374 2020
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker disease BEFREE Efficient silencing of CD47 and PD-L1 versus single gene silencing in vivo by systemic administration of LPP-P4-Ep could significantly inhibited the growth of solid tumors in subcutaneous and reduced lung metastasis in lung metastasis model. 30878596 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 AlteredExpression disease BEFREE These results identify DRG2 as a critical regulator of VEGF-A expression and of growth of PMs and lung metastases. 31693298 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation disease BEFREE Previous case reports and research have suggested an association between EGFR gene mutation and miliary patterned lung metastases in non-small cell lung cancer. 31151972 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker disease BEFREE Intratumoral infiltrating lymphocytes and peritumoral renal infiltrating lymphocytes, lymphocyte subpopulations (CD4<sup>+</sup>, CD8<sup>+</sup>), PD-1, PD-L1 were explored in paired samples of primary RCC (T) and respective pulmonary metastases (M). 30702014 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 Biomarker disease BEFREE Lung metastases 1 to 5 (median 2); 16/65 had previous liver metastases; carcinoembryonic antigen normal in 55/65. 31831062 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker disease BEFREE The combination of PD-L1 antibody and chemoimmunotherapy PTX/αGC/TH-Lip provides a promising strategy for enhancing treatment for melanoma and lung metastasis. 30635795 2019
Entrez Id: 7431
Gene Symbol: VIM
VIM
0.100 AlteredExpression disease BEFREE Hence, ATM modulates vimentin expression to facilitate IL-6-induced epithelial-mesenchymal transition and metastasis in lung cancer, indicating that ATM and vimentin might be potential therapeutic targets for inflammation-associated lung cancer metastasis. 31100307 2019
Entrez Id: 1822
Gene Symbol: ATN1
ATN1
0.100 GeneticVariation disease BEFREE CPEB2KO, but not wild-type cells produced lung colonies upon intravenous injection and subcutaneous tumors and spontaneous lung metastases upon implantation at mammary sites in NOD/SCID/IL2Rϒ-null mice, identified with HLA immunostaining. 31185986 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 Biomarker disease BEFREE We examined the mutation statuses of the KRAS 12/13/61/146, NRAS 12/13/61/146, and BRAF 600 codons in genomic DNA from fresh-frozen or formalin-fixed paraffin-embedded tissues derived from 34 primary lesions and 52 corresponding PMs from 36 patients with CRC. 31773354 2019
Entrez Id: 1048
Gene Symbol: CEACAM5
CEACAM5
0.100 AlteredExpression disease BEFREE High CA19-9 levels (> 24 U/ml) were significantly associated with poorly differentiated tumors, abnormal carcinoembryonic antigen (CEA) levels, and a high cumulative incidence of lung metastasis. 31333798 2019
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE LRP6N prevented SDF-1/CXCR4-induced metastasis to lung and prolonged survival in mice bearing breast tumors, whereas LRP6 knockdown activated SDF-1/CXCR4 signal transduction and promoted lung metastasis and tumor death. 31010839 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.100 Biomarker disease BEFREE Chemotherapy-elicited EVs are enriched in annexin A6 (ANXA6), a Ca<sup>2+</sup>-dependent protein that promotes NF-κB-dependent endothelial cell activation, Ccl2 induction and Ly6C<sup>+</sup>CCR2<sup>+</sup> monocyte expansion in the pulmonary pre-metastatic niche to facilitate the establishment of lung metastasis. 30598531 2019
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 Biomarker disease BEFREE In this study, we propose a novel therapeutic approach based on anti-CXCR4 blocking antibody in combination with NKAE cell therapy to prevent rhabdomyosarcoma tumor implantation and lung metastasis. 31428099 2019
Entrez Id: 10630
Gene Symbol: PDPN
PDPN
0.100 Biomarker disease BEFREE In an experimental lung metastasis model, the pharmacological depletion of CLEC-2 from platelets in mice resulted in a marked reduction of lung metastasis of podoplanin-expressing B16F10 cells. 31808911 2019
Entrez Id: 1822
Gene Symbol: ATN1
ATN1
0.100 Biomarker disease BEFREE These lines were examined for proliferation, invasion, and growth in soft agar <i>in vitro.</i> DU145 EV and FAM84B cells were investigated for tumor growth and lung metastasis in NOD/SCID mice. 31205500 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 Biomarker disease BEFREE The 37 MSS BRAF-mCRC cases were characterized by a greater stromal component (P = .0002), pulmonary metastases (P = .095), and p53 and synaptophysin immunoreactivity (P = .004 and P = .001, respectively). 30638691 2019
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
0.100 Biomarker disease BEFREE Although ablation of β1 or β3 integrin alone has limited effects on ErbB2-driven mammary tumorigenesis, deletion of both receptors resulted in a significant delay in tumor onset with a corresponding impairment in lung metastasis. 31618629 2019