Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Osteopontin (OPN) is identified as a diagnostic and prognostic biomarker of tumor progression and metastasis. 31792339 2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE These results demonstrate a novel mechanism of tumor progression mediated by OPN released in response to chemotherapy-generated tumor cell debris. 29957058 2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Osteopontin (SPP1) is a key extracellular matrix protein involved in several pathophysiological processes including cancer progression and metastasis. 31500540 2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Osteopontin (OPN), also known as SPP1 (secreted phosphoprotein 1), a secreted and chemokine-like glyco-phosphoprotein is involved in tumor progression such as cell proliferation, angiogenesis, and metastasis. 31028902 2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 AlteredExpression phenotype BEFREE Osteopontin (OPN) is a matricellular phosphoglycoprotein overexpressed in several tumor types and can activate several aspects of cancer progression in solid and non‑solid tumors. 30535434 2019
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Osteopontin (OPN) is involved in cell proliferation, migration, inflammation, and tumor progression in various tissues. 30177680 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 GeneticVariation phenotype BEFREE The metastasis gene osteopontin is alternatively spliced only in transformed cells, and the variants promote tumor progression. 30542698 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE In the present study, we focused on the therapeutic role of osteopontin (OPN), a secreted glycosylated phosphoprotein, involved in a number of physiological events including bone formation and remodeling, immune responses, and tumor progression. 29110207 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Osteopontin (OPN) is a promoter for tumor progression. 29535539 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 AlteredExpression phenotype BEFREE Osteopontin (OPN) spliced variants (OPN-SV: OPNa, OPNb, and OPNc) are aberrantly expressed in tumors and frequently associated with cancer progression. 30274371 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Loss of microenvironment-derived OPN enhanced tumor progression. 29016864 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 AlteredExpression phenotype BEFREE The present study detected the expression levels of OPN and evaluated its role in tumor progression in patients with non-small cell lung cancer (NSCLC). 30275702 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Osteopontin (OPN) is a glycoprotein involved in regulation of various influences on tumor progression, such as 29580029 2018
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE In this review, we will describe the role of systemic, tumor-derived, and stroma-derived OPN, highlighting its pivotal role at the crossroads of inflammation and tumor progression. 28769537 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE There is growing evidence to suggest that osteopontin (OPN) may play a critical role in tumor progression and metastasis. 27578008 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE In various adult neoplasms OPN was shown to correlate with cancer progression, invasiveness and metastasis. 28326824 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 AlteredExpression phenotype BEFREE OPN is upregulated in human colon cancers, and is suggested to enhance cancer progression. 28505114 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 GeneticVariation phenotype BEFREE Osteopontin splice variants and polymorphisms in cancer progression and prognosis. 28254527 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Osteopontin (OPN) plays an important role in cancer progression, however its prognostic significance and its downstream factors are largely elusive. 29209142 2017
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Extensive studies have elucidated the critical role of OPN in cell signaling such as regulation of cell proliferation, migration, inflammation, fibrosis and tumor progression. 27570486 2016
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Osteopontin (OPN) is a phosphoprotein that activates several aspects of tumor progression. 26404131 2016
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE OPN is a well-known multifunctional factor involved in various aspects of cancer progression, including endometrial cancer. 26509489 2015
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Osteopontin, a secreted glycoprotein, plays a role in cell survival, immunity, and tumor progression, its expression being associated with a poor prognosis and metastasis in several malignancies. 25824779 2015
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE Our results support that osteopontin regulates ICAM-1 and VEGFA expression mainly in triple-negative/basal-like breast carcinomas, suggesting a relevant role in the pathogenesis and tumor progression of this molecular subtype. 25972323 2015
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 AlteredExpression phenotype BEFREE We have previously demonstrated that CBX7 is able to inhibit the expression of the SPP1 gene, encoding the chemokine osteopontin that is over-expressed in cancer and has a critical role in cancer progression. 25595895 2015