Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.370 GeneticVariation disease BEFREE Our data showed that primary SC/ADC and the recurrent SC shared multiple gene mutations including EGFR, NF1, TP53, CDKN2B, and SMARCA4, while both primary and recurrent SCs had a unique TP53 exon 4 splicing mutation frequently observed in sarcoma. 31208361 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.370 GeneticVariation disease BEFREE Spindle cell carcinomas lacked TP53 mutations, in contrast to other subtypes (78%, p = 0.003). 29946183 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.370 Biomarker disease CTD_human Unventilated indoor coal-fired stoves in Guizhou province, China: cellular and genetic damage in villagers exposed to arsenic in food and air. 17450239 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.370 GeneticVariation disease BEFREE The two distinct components, sarcomatous and carcinomatous components in SPCC, were analyzed independently. p53 mutations were detected in both components of SPCC (50.0%, 8/16), and those in the sarcomatous component were completely in accordance with those in the carcinomatous one. 14767509 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.370 Biomarker disease CTD_human Human papillomavirus DNA and p53 status in penile carcinomas. 9626339 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.370 GeneticVariation disease BEFREE This analytical approach demonstrated p53 missense point mutations in four of nine cases of spindle cell carcinoma with a 100% concordance rate between p53 immunopositivity and the presence of DNA mutational damage. 9236836 1997
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.370 GeneticVariation disease BEFREE Pleomorphic (giant and spindle cell) carcinoma is genetically distinct from adenocarcinoma and squamous cell carcinoma by K-ras-2 and p53 analysis. 8853037 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.370 GeneticVariation disease BEFREE Alteration of the p53 gene of lung carcinomas with sarcomatous transformation (spindle cell carcinoma): analysis of four cases. 10846548 1996
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.370 AlteredExpression disease BEFREE Abnormalities in tumor suppressor gene p53 expression also were found in two of the 11 SpCC cases using monoclonal antibody PAb 1801. 8276377 1993
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.360 GeneticVariation disease BEFREE High PD-L1 expression (using a ≥50% cutoff) was significantly associated with male sex (P = 0.001), ever smoking history (P < 0.001), squamous cell carcinoma (P = 0.001), large cell carcinoma (P < 0.001), lymphoepithelioma-like carcinoma (P = 0.006), sarcomatoid carcinoma (P < 0.001), mutant KRAS (P = 0.005) and wild-type EGFR (P = 0.003). 29713040 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.360 GeneticVariation disease BEFREE KRAS mutation is predictive of outcome in patients with pulmonary sarcomatoid carcinoma. 29489023 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.360 GeneticVariation disease BEFREE Three (37.5%) KRAS mutations were detected in sarcomatoid carcinoma. 26486077 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.360 GeneticVariation disease BEFREE Combining p53(R273H) with KRAS(G12V) activation caused transformation of MOE into high-grade sarcomatoid carcinoma when xenografted into nude mice. 25810107 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.360 Biomarker disease CTD_human SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene. 20565773 2010
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.360 GeneticVariation disease BEFREE In this study, no mutation was detected in the K-ras gene of either the SpCC or SCC group. 16731596 2007
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.360 Biomarker disease CTD_human Strain-dependent lung tumor formation in mice transplacentally exposed to 3-methylcholanthrene and post-natally exposed to butylated hydroxytoluene. 10545420 1999
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.360 Biomarker disease BEFREE Pleomorphic (giant and spindle cell) carcinoma is genetically distinct from adenocarcinoma and squamous cell carcinoma by K-ras-2 and p53 analysis. 8853037 1996
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.340 GeneticVariation disease BEFREE Our data showed that primary SC/ADC and the recurrent SC shared multiple gene mutations including EGFR, NF1, TP53, CDKN2B, and SMARCA4, while both primary and recurrent SCs had a unique TP53 exon 4 splicing mutation frequently observed in sarcoma. 31208361 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.340 GeneticVariation disease BEFREE Lung cancers have various acquired resistance mechanisms that lead to treatment failure and disease progression, including secondary epidermal growth factor receptor (EGFR) exon 20 T790 M mutations, EGFR downstream or bypass pathway activation, and histologic transformation from adenocarcinoma to small cell carcinoma, squamous cell carcinoma, or sarcomatoid carcinoma. 31561203 2019
Entrez Id: 4233
Gene Symbol: MET
MET
0.340 GeneticVariation disease BEFREE Overall, the prevalence of MET exon 14 mutation in NSCLC was 3% (95% CI = 2-3), with being most commonly found in pulmonary sarcomatoid carcinoma (13%; 95% CI = 4-21). 30089599 2018
Entrez Id: 4233
Gene Symbol: MET
MET
0.340 GeneticVariation disease BEFREE The incidence of MET exon 14 mutations in sarcomatoid carcinoma was significantly higher than in other histologic types (P = .034). 29338938 2018
Entrez Id: 4233
Gene Symbol: MET
MET
0.340 GeneticVariation disease BEFREE A KIF5B-MET fusion variant in a patient with a mixed-type adenocarcinoma and sarcomatoid tumor was identified, and another case was found in a pulmonary sarcomatoid carcinoma patient. 30015159 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.340 GeneticVariation disease BEFREE Using histological and gene sequencing analysis, we observed that the primary adenocarcinoma acquired T790M mutation in EGFR exon 20, and a secondary sarcomatoid carcinoma developed in the vicinity. 28786540 2017
Entrez Id: 4233
Gene Symbol: MET
MET
0.340 GeneticVariation disease BEFREE The high incidence of METΔ14 mutation in sarcomatoid carcinoma suggested that MET inhibition might benefit this specific subgroup of patients.Clin Cancer Res; 22(12); 3048-56. 26847053 2016
Entrez Id: 4233
Gene Symbol: MET
MET
0.340 Biomarker disease CTD_human HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma. 20661229 2011