Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 Biomarker disease BEFREE IGF2 role in adrenocortical carcinoma biology. 31378849 2019
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease BEFREE We previously demonstrated that, in adrenocortical carcinoma (ACC), ERα is upregulated and that estradiol activates the IGF-II/IGF1R signaling pathways defining the role of this functional cross-talk in H295R ACC cell proliferation. 29112114 2017
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 GeneticVariation disease BEFREE Key molecular events that contribute to formation of adrenocortical cancer are IGF2 overexpression, TP53-inactivating mutations, and constitutive activation of the Wnt/b-catenin signalling pathway via activating mutations of the b-catenin gene. 27387247 2016
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 Biomarker disease BEFREE Methylation of IGF2 regulatory regions to diagnose adrenocortical carcinomas. 27535174 2016
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 Biomarker disease BEFREE We have previously demonstrated that estrogen receptor (ER) alpha (ESR1) increases proliferation of adrenocortical carcinoma (ACC) through both an estrogen-dependent and -independent (induced by IGF-II/IGF1R pathways) manner. 26131713 2015
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 Biomarker disease BEFREE Overexpression of insulin growth factor 2 (IGF2) is a hallmark of adrenocortical carcinomas and pheochromocytomas. 26400872 2015
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 Biomarker disease BEFREE IGF2 promotes growth of adrenocortical carcinoma cells, but its overexpression does not modify phenotypic and molecular features of adrenocortical carcinoma. 25089899 2014
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 Biomarker disease CTD_human Everolimus therapy for progressive adrenocortical cancer. 23417626 2013
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 GeneticVariation disease BEFREE Abnormal methylation at the IGF2/H19 locus is common in adrenocortical carcinomas. 23093492 2013
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 Biomarker disease BEFREE p53 Stabilization induces cell growth inhibition and affects IGF2 pathway in response to radiotherapy in adrenocortical cancer cells. 23028800 2012
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease BEFREE Previous studies have identified overexpression of insulin-like growth factor 2 (IGF-2) and constitutive activation of β-catenin as key factors involved in the development of adrenocortical carcinoma. 21386792 2011
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 Biomarker disease CTD_human Clinicopathological features, biochemical and molecular markers in 5 patients with adrenocortical carcinoma. 21521927 2011
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease LHGDN Otherwise, IGF-II was mainly overexpressed in adult adrenocortical carcinomas (270.5 +/- 130.2 vs. 16.1 +/- 13.3; P = 0.0001). 18611974 2008
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease BEFREE IGF-II overexpression has been consistently demonstrated in adult adrenocortical carcinomas. 18611974 2008
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 GeneticVariation disease BEFREE Because the overexpression of the IGF-II gene is a frequent feature of adrenal carcinoma, we searched for the presence of GHRH-R SVs in these tumours. 15853821 2005
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 GeneticVariation disease BEFREE The genetic predisposition to adrenocortical cancer in children has been well established in the Li-Fraumeni and Beckewith-Wiedeman syndromes due to germline p53 mutation located at 17p13 and dysregulation of the imprinted IGF-2 locus at 11p15, respectively. 16001332 2005
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease BEFREE It is evident, therefore, that high levels of IGF-II in combination with overexpression of the IGF-I-receptor can provide a significant growth advantage for adrenocortical carcinoma cells and thus contribute to the highly malignant phenotype of this rare type of cancer. 15241731 2004
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease BEFREE RNA analysis indicated that the adrenocortical carcinomas expressed less H19 but more IGF-II RNAs than normal adrenal tissues did. 11889182 2002
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease BEFREE The xenografts precisely reproduced the dysregulation of the insulin-like growth factor (IGF) system [overexpression of the IGF-II and IGF-binding protein-2 (IGFBP-2) genes] typical of adrenocortical carcinoma. 10965887 2000
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 Biomarker disease BEFREE Autocrine role of IGF-II in proliferation of human adrenocortical carcinoma NCI H295R cell line. 10425444 1999
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease BEFREE Hormonally active adrenocortical carcinomas and virilizing adenomas express insulin-like growth factor II gene abundantly. 9694575 1998
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease BEFREE IGF2 is often overexpressed in many tumours including adrenal carcinomas. 9367863 1997
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease BEFREE The decreased expression of both p57KIP2 and H19 RNAs in conjunction with elevated IGF-II mRNA expression in hormonally active adrenocortical carcinomas suggests that the loss of expression of the putative tumor suppressor genes p57KIP2 and H19 may be involved in the pathogenesis of these neoplasms. 9177379 1997
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 AlteredExpression disease BEFREE In four hormonally active adrenocortical carcinomas, very low levels of H19 ribonucleic acid (RNA) were detected, whereas IGF-II was highly expressed. 7531713 1995
Entrez Id: 3481
Gene Symbol: IGF2
IGF2
0.500 Biomarker disease BEFREE IGF-II mRNA levels were more than 10-fold higher in hormonally active adrenocortical carcinomas than in normal adult adrenals, and increased IGF-II-like immunoreactivity was detectable in these carcinomas. 8370710 1993