Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.350 | GeneticVariation | disease | BEFREE | BAP1-TPDS is associated with an increased risk of developing uveal melanoma (UM), cutaneous melanoma (CM), malignant mesothelioma (MMe), renal cell carcinoma (RCC), meningioma, cholangiocarcinoma, multiple non-melanoma skin cancers, and <i>BAP1</i>-inactivated nevi. | 31382694 | 2019 | ||||
|
0.350 | Biomarker | disease | BEFREE | The deubiquitinating enzyme BAP1 is a tumor suppressor, among others involved in cholangiocarcinoma. | 31130514 | 2019 | ||||
|
0.350 | GeneticVariation | disease | BEFREE | Although the pooled results demonstrated that BAP1 mutation was a negative indicator of overall survival (hazard ratio = 1.73; 95% confidence interval = 1.23-2.42) and disease-free survival (hazard ratio = 2.25; 95% confidence interval = 1.47-3.45), this prognostic value was only applicable to uveal melanoma and clear cell renal cell carcinoma, but not to malignant pleural mesothelioma or cholangiocarcinoma. | 28618948 | 2017 | ||||
|
0.350 | Biomarker | disease | BEFREE | A BAP1 dependent alteration in expression of lncRNA NEAT-1 was identified by RT-PCR based lncRNA expression profiling, and an inverse relationship between this lncRNA and BAP1 was observed in analysis of the Tumor Cancer Genome Atlas cholangiocarcinoma dataset. | 28122578 | 2017 | ||||
|
0.350 | Biomarker | disease | BEFREE | BAP1 is a tumor suppressor gene that is lost or deleted in diverse cancers, including uveal mela¬noma, malignant pleural mesothelioma (MPM), clear cell renal carcinoma, and cholangiocarcinoma. | 25830670 | 2015 | ||||
|
0.350 | Biomarker | disease | CTD_human | Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area. | 25231345 | 2015 | ||||
|
0.350 | Biomarker | disease | CTD_human | Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. | 24185509 | 2013 |