Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.320 | AlteredExpression | disease | BEFREE | While retaining normal systemic iron levels, this model developed PAH and right heart failure as a consequence of intracellular iron deficiency and increased expression of the vasoconstrictor endothelin-1 (ET-1) within PASMCs.PAH was prevented and reversed by i.v. iron and by the ET receptor antagonist BQ-123. | 31152133 | 2019 | ||||
|
0.320 | Biomarker | disease | BEFREE | However, positive staining for ET-1 was also seen in rats' hearts that suffered from arrhythmias after electric shock and in the myocardium of the right ventricle in human control cases in which a right heart failure has to be discussed. | 29151120 | 2018 | ||||
|
0.320 | Biomarker | disease | CTD_human | The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in the Valsartan Heart Failure Trial (Val-HeFT). | 16762801 | 2006 | ||||
|
0.320 | Biomarker | disease | CTD_human | The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. | 16360360 | 2005 | ||||
|
0.320 | Biomarker | disease | CTD_human | Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes. | 11707688 | 2001 | ||||
|
0.320 | Biomarker | disease | CTD_human | Effects of combination of ACE inhibitor and angiotensin receptor blocker on cardiac remodeling, cardiac function, and survival in rat heart failure. | 11136700 | 2001 | ||||
|
0.320 | Biomarker | disease | CTD_human | Acute effects of an endothelin-1 receptor antagonist bosentan at different stages of heart failure in conscious dogs. | 9861300 | 1998 | ||||
|
0.320 | Biomarker | disease | CTD_human | Effects of endothelin-1 on renal function in humans: implications for physiology and pathophysiology. | 7967349 | 1994 | ||||
|
0.320 | Biomarker | disease | CTD_human | Plasma endothelin-1 and doxorubicin cardiotoxicity. | 7969316 | 1994 |