Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 AlteredExpression disease BEFREE While retaining normal systemic iron levels, this model developed PAH and right heart failure as a consequence of intracellular iron deficiency and increased expression of the vasoconstrictor endothelin-1 (ET-1) within PASMCs.PAH was prevented and reversed by i.v. iron and by the ET receptor antagonist BQ-123. 31152133 2019
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease BEFREE However, positive staining for ET-1 was also seen in rats' hearts that suffered from arrhythmias after electric shock and in the myocardium of the right ventricle in human control cases in which a right heart failure has to be discussed. 29151120 2018
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human The prognostic value of big endothelin-1 in more than 2,300 patients with heart failure enrolled in the Valsartan Heart Failure Trial (Val-HeFT). 16762801 2006
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human The effects of atorvastatin (10 mg) on systemic inflammation in heart failure. 16360360 2005
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes. 11707688 2001
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human Effects of combination of ACE inhibitor and angiotensin receptor blocker on cardiac remodeling, cardiac function, and survival in rat heart failure. 11136700 2001
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human Acute effects of an endothelin-1 receptor antagonist bosentan at different stages of heart failure in conscious dogs. 9861300 1998
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human Effects of endothelin-1 on renal function in humans: implications for physiology and pathophysiology. 7967349 1994
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.320 Biomarker disease CTD_human Plasma endothelin-1 and doxorubicin cardiotoxicity. 7969316 1994