Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status. 31177911 2020
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE The Loss of <i>SMAD4/DPC4</i> Expression Associated with a Strongly Activated Hedgehog Signaling Pathway Predicts Poor Prognosis in Resected Pancreatic Cancer. 31417657 2019
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 GeneticVariation disease BEFREE As a central player in TGF-β signal transduction, SMAD4 (also known as DPC4) is frequently mutated or deleted in gastrointestinal and pancreatic cancer. 30664791 2019
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE We explored the role of S100A11 in the proliferation and apoptosis of pancreatic cancer cell line PANC-1 and the potential mechanisms involving the TGF-β<sub>1</sub>/SMAD4/p21 pathway. 29922945 2019
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer. 31611300 2019
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 AlteredExpression disease BEFREE More interestingly, we observed that the protein level of SMAD4 is inversely correlated with autophagy in orthotopic tumor tissue samples.<b>Conclusions:</b> Our results demonstrate that defective <i>SMAD4</i> is responsible for radioresistance in pancreatic cancer through induction of ROS and increased level of radiation-induced autophagy.<i></i>. 29602802 2018
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE However, <i>smad4/DPC4</i> is also mutated in other conditions and cancers such as juvenile polyposis syndrome with and without hereditary haemorrhagic telangiectasia, colorectal and prostate cancers.Immunohistochemistry for smad4/DPC4 protein is most useful in separating benign/reactive conditions from pancreatic cancer in needle/core biopsies. 29720405 2018
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE Radiofrequency ablation for locally advanced pancreatic cancer: SMAD4 analysis segregates a responsive subgroup of patients. 28983662 2018
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE Utility of Assessing the Number of Mutated KRAS, CDKN2A, TP53, and SMAD4 Genes Using a Targeted Deep Sequencing Assay as a Prognostic Biomarker for Pancreatic Cancer. 28099251 2017
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 GeneticVariation disease BEFREE The combination of mutant KRAS with a single inactivating TP53, SMAD4 or CDKN2A mutation in genetically engineered mouse models (GEMMs) showed that these mutations exert different synergistic effects in PC. 28475592 2017
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE The most consistently mutated genes are <i>KRAS, CDKN2A, TP53</i>, and <i>SMAD4/DPC4</i> Study of familial PDAC has led to the recognition that a variety of defects in DNA repair genes can be associated with the emergence of pancreatic cancer. 28373361 2017
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE SUVmax can predict loss of SMAD4 in resected left-sided pancreatic cancer. 27124039 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE We have tested nanopore sequencing to detect a series of well-characterized SVs, including large deletions, inversions, and translocations that inactivate the CDKN2A/p16 and SMAD4/DPC4 tumor suppressor genes in pancreatic cancer. 26787508 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE Eighteen phenotypic markers representing 11 types of IIC and the protein products of genes TP53, CDKN2A/p16 and SMAD4/DPC4 were assessed by immunohistochemistry of specimens from patients with pancreatic cancer. 27256393 2016
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE In this review, we summarize the role of several miRNAs that regulate various oncogenes (KRAS) and tumor suppressor genes (p53, p16, SMAD4, etc.) involved in PC development, their prospective roles as diagnostic and prognostic markers and as a therapeutic targets. 25453266 2015
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE We investigated how maintenance of pancreatic cancer-initiating cells is influenced by Smad4, which is frequently deleted or mutated in pancreatic cancers cells. 25769430 2015
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 AlteredExpression disease BEFREE MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4. 26019136 2015
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 AlteredExpression disease BEFREE DPC4/SMAD4 mutations are associated with aggressive pancreatic cancer.In this issue of Cell, Whittle et al. demonstrate that Runx3 expression combined with Dpc4/Smad4 status can predict the metastatic propensity of pancreatic tumors, providing valuable guidance for personalized therapy for patients with pancreatic cancer. 26046433 2015
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE Other genetic alterations, including telomere shortening and the inactivation of tumor suppressor genes such as CDKN2A, TP53, and SMAD4, which encode p16, p53, and SMAD4, respectively, also contribute to the progression of pancreatic cancer. 24445769 2015
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE This study was performed to examine the expression patterns and association of Jab1 and Smad4 in PC cells for gaining a further understanding of PC pathogenesis. 26464677 2015
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-β Signaling. 26284758 2015
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 GeneticVariation disease BEFREE Transforming growth factor, beta (TGFB) signal is considered to be a tumor suppressive pathway based on the frequent genomic deletion of the SMAD4 gene in pancreatic cancer (PC); however; the role of the activin signal, which also belongs to the TGFB superfamily, remains largely unclear. 24886203 2014
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 AlteredExpression disease BEFREE We found that (i) differentially expressed whole cell and cytoplasm RNA levels are both poor predictors of polysome RNA levels; (ii) for a majority of RNAs, differential RNA levels are regulated independently in the nucleus, cytoplasm, and polysomes; (iii) for most of the remaining polysome RNA, levels are regulated via a "tagging" of the RNAs in the nucleus for rapid entry into the polysomes; (iv) a SMAD4-dependent pathway appears to indeed play a role in regulating mRNA entry into polysomes; and (v) a gene list derived from differentially expressed polysome RNA in BxPC3 cells generated new candidate genes and cell pathways potentially related to pancreatic cancer. 22965423 2012
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 Biomarker disease BEFREE Genetic alterations of KRAS, CDKN2A, TP53, and SMAD4 are the most frequent events in pancreatic cancer. 22991414 2012
Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
0.700 GeneticVariation disease BEFREE Genetic mutations, such as activation of the KRAS2 oncogene, inactivation of the tumor-suppressor gene CDKN2A, inactivation of the tumor-suppressor gene TP53 and deleted in pancreatic cancer 4 (DPC4) gene defects are seen in those with pancreatic cancer. 23393682 2012