Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease BEFREE This study illustrated that LINC01420 accelerates PC progression through releasing miR-494-3p-silenced MYC in cytoplasm and upregulating MYC-activated KRAS in nucleus, unveiling LINC01420 as a latent therapeutic strategy for PC patients. 31562613 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease BEFREE miR-29a is repressed by MYC in pancreatic cancer and its restoration drives tumor suppressive effects via downregulation of LOXL2. 31662451 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 GeneticVariation disease BEFREE Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. 31311847 2019
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease BEFREE Mutant KRAS and c-MYC are oncogenic drivers and rational therapeutic targets for the treatment of pancreatic cancer. 28249168 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease BEFREE We investigated the therapeutic potential of a new oligonucleotide-mediated gene silencing technology (U1 Adaptor) targeting KRAS and MYC in pancreatic cancer. 28377488 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease BEFREE A combined approach targeting HDAC1/HDAC2 and MYC may present a novel and molecularly defined strategy to target mutant p53 in pancreatic cancer. 27721407 2017
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease BEFREE MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies. 26119937 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease BEFREE Concepts to Target MYC in Pancreatic Cancer. 27406986 2016
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease BEFREE Furthermore, MYC blocking in SATB1-overexpressing cells attenuated the promotion of pancreatic cancer cell growth and invasion. 26108419 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 AlteredExpression disease BEFREE GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1. 25807524 2015
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease BEFREE Indeed, in some PDA cell lines, RNA interference-mediated silencing of c-MYC expression had antiproliferative effects similar to that of MEK inhibition, thereby highlighting the importance of c-MYC in key aspects of pancreatic cancer cell maintenance. 22833572 2012
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 AlteredExpression disease BEFREE We find that MYC knockdown by RNA interference suppresses PEG10 expression in Panc1 pancreatic carcinoma and HepG2 hepatocellular carcinoma cells and that knockdown of PEG10 inhibits the proliferation of Panc1, HepG2, and Hep3B cells. 16423995 2006
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease BEFREE We conclude that deregulation of c-MYC protein is common in pancreatic cancer and that it may be involved in early neoplastic development and progression rather than in locoregional spread of invasive cancer. 11950922 2002
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.300 Biomarker disease MGD