Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.370 | Biomarker | disease | BEFREE | Taken together, our results demonstrate that hyperglycemia enhances cell invasive ability through the SOD2/H2O2/MAPK axis in human pancreatic cancer. | 26439801 | 2015 | ||||
|
0.370 | AlteredExpression | disease | BEFREE | Our results suggest that upregulation of SOD2 expression is an important mechanism by which pancreatic cancer cells acquire resistance to ROS-inducing, anticancer drugs, and potentially also to IR. | 22547077 | 2012 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [rs4880" genes_norm="1429;6648;6649">Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [rs1800566;rs1258159645" genes_norm="1728">Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684) with pancreatic cancer risk was studied. | 20966810 | 2011 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | Moreover, the SOD2 -1221G>A AA genotype carriers had a significantly increased risk for pancreatic cancer among those with a low dietary vitamin E intake but decreased risk among those with a high vitamin E intake (P(interaction) = 0.002). | 20097730 | 2010 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | Polymorphisms of the inflammatory pathway genes MPO -G463A and SOD2 Ala16Val are associated with elevated pancreatic cancer risk. | 18205184 | 2008 | ||||
|
0.370 | GeneticVariation | disease | BEFREE | Delivery of the GPx gene alone or in combination with the MnSOD gene may prove beneficial for treatment of pancreatic cancer. | 15018733 | 2004 | ||||
|
0.370 | Biomarker | disease | BEFREE | Delivery of the MnSOD gene may prove beneficial for suppression of pancreatic cancer growth. | 12700280 | 2003 | ||||
|
0.370 | Biomarker | disease | CTD_human | Invited review: manganese superoxide dismutase in disease. | 11328670 | 2001 |